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In the second case, the hepatomegaly was moderate, and with conservative treatment in the neonatal period the outcome was good. In the third case, hepatomegaly was mild and improved spontaneously, and the hematological abnormalities required only conservative treatment in the neonatal period. Our experience raises the question of whether fetal hepatosplenomegaly is a predictor of transient myeloproliferative disorder with trisomy 21 and whether the degree of fetal hepatomegaly is a marker for the neonatal severity of hematological abnormalities. Copyright \u00a9 2004 ISUOG. Published by John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/uog.1054","type":"journal-article","created":{"date-parts":[[2004,5,24]],"date-time":"2004-05-24T12:00:56Z","timestamp":1085400056000},"page":"83-85","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Is the degree of fetal hepatosplenomegaly with transient abnormal myelopoiesis closely related to the postnatal severity of hematological abnormalities in Down syndrome?"],"prefix":"10.1002","volume":"24","author":[{"given":"M.","family":"Ogawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Hosoya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,5,24]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"crossref","first-page":"3098","DOI":"10.1182\/blood.V82.10.3098.3098","article-title":"Trisomy 21 in childhood acute lymphoblastic leukemia: a Pediatric Oncology Group study (8602)","volume":"82","author":"Watson MS","year":"1993","journal-title":"Blood"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(87)90354-2"},{"key":"e_1_2_4_4_2","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1182\/blood.V36.4.443.443","article-title":"A neonate with Down's syndrome and transient abnormal myelopoiesis: serial blood and bone marrow studies","volume":"36","author":"Nagao T","year":"1970","journal-title":"Blood"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0146-0005(97)80025-0"},{"key":"e_1_2_4_6_2","first-page":"569","article-title":"Transient abnormal myelopoiesis in a chromosomally normal newborn infant","volume":"35","author":"Shima Y","year":"1999","journal-title":"Acta Neonat Jpn"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)90592-S"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(11)90761-3"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1998.11060453.x"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(63)80296-6"},{"key":"e_1_2_4_11_2","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1182\/blood.V55.4.691.691","article-title":"Transient leukemoid reaction and trisomy 21 mosaicism in a phenotypically normal newborn","volume":"55","author":"Brodeur GM","year":"1980","journal-title":"Blood"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.3109\/15513819309048267"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1159\/000264219"},{"key":"e_1_2_4_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.1999.tb03461.x"},{"key":"e_1_2_4_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2001.00384.x"},{"key":"e_1_2_4_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2001.00362.x"},{"key":"e_1_2_4_17_2","first-page":"162","article-title":"Fetal liver ultrasound measurements in isoimmunized pregnancies","volume":"68","author":"Vintzileos AM","year":"1986","journal-title":"Obstet Gynecol"},{"key":"e_1_2_4_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(89)90229-9"},{"key":"e_1_2_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(99)90125-9"},{"key":"e_1_2_4_20_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V80.6.1521.1521"},{"key":"e_1_2_4_21_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-999339"}],"container-title":["Ultrasound in Obstetrics &amp; 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