{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:00:47Z","timestamp":1777417247098,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,5,4]],"date-time":"2004-05-04T00:00:00Z","timestamp":1083628800000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2004,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the outcome of euploid fetuses with increased nuchal translucency thickness (NT) expressed in multiples of the median (MoM) or delta\u2010NT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Included in the study were euploid fetuses with increased <jats:italic>NT<\/jats:italic> \u2265 95<jats:sup>th<\/jats:sup> centile, for which information about pregnancy outcome was available. The following parameters were defined as an adverse outcome: miscarriage, structural anomalies justifying termination of pregnancy, and structural anomalies, genetic syndromes and neurodevelopmental problems diagnosed postnatally. Fetal outcome according to NT MoM and delta\u2010NT was calculated using different cut\u2010off values. Calculations of the odds ratio for adverse outcome were performed using either NT MoM or delta\u2010NT as a predictor in logistic regression models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study comprised 168 euploid fetuses. Of these, 38 (23%) had an adverse outcome: 11 (6%) had miscarriages, 14 (8%) were terminated because of fetal abnormalities detected on the prenatal scan and 13 (7%) were found postnatally to have abnormalities. The incidence of cases exhibiting an adverse outcome was 5.3%, 19.2% and 58.5% for NT values of 1.6\u20131.9, 2.0\u20133.0 and &gt;3.0 MoM, respectively (<jats:italic>P<\/jats:italic> &lt; 0.0001, \u03c7<jats:sup>2<\/jats:sup> test), and 3.9%, 16.7% and 62.8% for delta\u2010NT values of 1.0\u20131.4, 1.5\u20132.5 and &gt;2.5 mm, respectively (<jats:italic>P<\/jats:italic> &lt; 0.0001, \u03c7<jats:sup>2<\/jats:sup> test). Using cut\u2010offs of 2.0 MoM and delta\u2010NT of 1.5 mm, the odds ratios for adverse outcome were 10.2 (95% CI, 3.4\u201330.4) and 15.4 (95% CI, 4.2\u201343.6), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Both the NT MoM and delta\u2010NT approaches may be used to determine cases which require additional antenatal investigation as well as fetal karyotyping. For this purpose we suggest using a cut\u2010off of either 2.0 MoM or a delta\u2010NT of 1.5 mm. Copyright \u00a9 2004 ISUOG. Published by John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.1060","type":"journal-article","created":{"date-parts":[[2004,5,4]],"date-time":"2004-05-04T10:01:11Z","timestamp":1083664871000},"page":"477-481","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Comparison of pregnancy outcome of euploid fetuses with increased nuchal translucency (NT) expressed in NT MoM or delta\u2010NT"],"prefix":"10.1002","volume":"23","author":[{"given":"R.","family":"Maymon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Tercanli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Dreazen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Sartorius","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Holzgreve","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Herman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,5,4]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1995.tb10902.x"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)11280-6"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199712043372303"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/pd.413"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2001.00454.x"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.304.6831.867"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2002.00533_4.x"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/15.9.2023"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2001.00341.x"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2002.00835.x"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1975.tb00710.x"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1998.12060398.x"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2000.00035.x"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199805)18:5<519::AID-PD398>3.0.CO;2-U"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.186"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/14.2.556"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2001.00321.x"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2001.00483.x"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1998.11060401.x"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.72.857.10505009"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1998.11060391.x"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/pd.399"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2001.00481.x"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/pd.321"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(03)00206-6"}],"container-title":["Ultrasound in Obstetrics &amp; 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