{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T18:00:15Z","timestamp":1773424815690,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,6,16]],"date-time":"2004-06-16T00:00:00Z","timestamp":1087344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001868","name":"National Science Council of Taiwan","doi-asserted-by":"crossref","award":["NSC 90-2314-B-002-452"],"award-info":[{"award-number":["NSC 90-2314-B-002-452"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2004,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Larsen syndrome consists of skeletal dysplasia with multiple joint dislocations and a characteristic facies. The basis of this abnormality is a generalized mesenchymal disorder involving connective tissues. We describe our findings in a woman who was referred at 28 weeks' gestation due to multiple fetal anomalies suspected initially at an 18\u2010week ultrasound examination. On three\u2010dimensional (3D) ultrasound we found the fetus had bilateral genu recurvatum. Further 3D examination at 36 weeks confirmed the lower limb anomaly and revealed facial anomalies that led to the diagnosis of Larsen syndrome. An elective Cesarean section was performed at 38 weeks' gestation to minimize neurological sequelae. Magnetic resonance imaging was performed postnatally and showed pachygyria, colpocephaly and agenesis of the corpus callosum. In this case, 3D ultrasound facilitated the prenatal diagnosis of Larsen syndrome. A careful prenatal investigation for other associated anomalies such as those of the cardiovascular or neurological systems is warranted with this diagnosis. These associated lesions are likely to have a greater impact on prognosis than the classic symptoms of Larsen syndrome and a collaborative approach is necessary to optimize delivery and postnatal management of an affected fetus. Copyright \u00a9 2004 ISUOG. Published by John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/uog.1080","type":"journal-article","created":{"date-parts":[[2004,6,25]],"date-time":"2004-06-25T07:00:50Z","timestamp":1088146850000},"page":"89-93","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Three\u2010dimensional ultrasound diagnosis of Larsen syndrome with further characterization of neurological sequelae"],"prefix":"10.1002","volume":"24","author":[{"given":"J. C.","family":"Shih","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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J.","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,6,16]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(50)80268-8"},{"key":"e_1_2_5_3_2","first-page":"1104","article-title":"Localization of a gene for autosomal dominant Larsen syndrome to chromosome region 3p21.1\u201314.1 in the proximity of, but distinct from, the COL7A1 locus","volume":"57","author":"Vujic M","year":"1995","journal-title":"Am J Hum Genet"},{"key":"e_1_2_5_4_2","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1542\/peds.71.6.942","article-title":"Cardiovascular manifestations in the Larsen syndrome","volume":"71","author":"Kiel EA","year":"1983","journal-title":"Pediatrics"},{"key":"e_1_2_5_5_2","first-page":"357","article-title":"Oral and craniofacial morphology of a patient with Larsen syndrome","volume":"6","author":"Tsang MC","year":"1986","journal-title":"J Craniofac Genet Dev Biol"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.1950050111"},{"key":"e_1_2_5_7_2","first-page":"270","article-title":"Larsen syndrome: clinical features and treatment\u2014a report of two cases","volume":"10","author":"Lutter LD","year":"1990","journal-title":"J Pediatr Orthop"},{"key":"e_1_2_5_8_2","first-page":"179","article-title":"A case of Larsen syndrome with severe cervical malformations","volume":"5","author":"Le Marec B","year":"1994","journal-title":"Genet Couns"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970110403"},{"key":"e_1_2_5_10_2","first-page":"845","article-title":"Prenatal diagnosis and obstetric management of Larsen syndrome","volume":"81","author":"Rochelson B","year":"1993","journal-title":"Obstet Gynecol"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.7863\/jum.1995.14.8.627"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2000.19.6.419"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0004.2000.570210.x"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-198705000-00024"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.3109\/17453678508992968"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004694-199903000-00023"},{"key":"e_1_2_5_17_2","first-page":"369","article-title":"Larsen syndrome associated with severe congenital hydrocephalus","volume":"12","author":"Caksen H","year":"2001","journal-title":"Genet Couns"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1977.tb07964.x"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1988.tb03468.x"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.1080","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.1080","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.1080","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,8]],"date-time":"2023-10-08T16:43:17Z","timestamp":1696783397000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.1080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,6,16]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,7]]}},"alternative-id":["10.1002\/uog.1080"],"URL":"https:\/\/doi.org\/10.1002\/uog.1080","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,6,16]]},"assertion":[{"value":"2004-01-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2004-06-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}