{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T18:59:58Z","timestamp":1775588398489,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,6,22]],"date-time":"2012-06-22T00:00:00Z","timestamp":1340323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Autopsies of fetuses with thanatophoric dysplasia (TD) have shown abnormal gyration of the temporal lobes. In addition, the head is relatively large compared with the abdomen. We evaluated by ultrasound six consecutive cases of TD at 19 + 0 to 19 + 6 gestational weeks based on last menstrual period. We observed abnormal and deep transverse sulci in the temporal lobes in all cases; these features were confirmed at autopsy. We performed biometric assessment, including biparietal diameter (BPD) and mean abdominal diameter (MAD). For each MAD value in the TD fetuses, we computed mean and SD of the corresponding BPD values from a population\u2010based registry in the relevant age range, and used them to calculate Z\u2010scores for each BPD\/MAD ratio. In the general population, the average BPD\/MAD ratio was 1.05. In the TD fetuses, the mean BPD was 51.5 (range, 49\u201354) mm, the MAD was 45 (range, 41\u201347) mm and the BPD\/MAD ratio was 1.15 (range, 1.09\u20131.20). The average Z\u2010score of the ratios for TD fetuses was 2.44 (range, 1.05\u20133.39). The ratios for the TD fetuses were significantly higher than were the population ratios (<jats:italic>P<\/jats:italic> = 0.016). At autopsy, the mean brain\u2010to\u2010body weight ratio was 20.6% (range, 15.4\u201324.1%), which was greater than the corresponding mean ratio of 14.9% in normal fetuses. We conclude that abnormal and deep transverse gyration of the temporal lobes can be visualized by ultrasound in mid\u2010second\u2010trimester fetuses with TD. Due to megalencephaly, fetuses with TD have significantly different body proportions, with a larger BPD compared with normal fetuses. Copyright \u00a9 2012 ISUOG. Published by John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/uog.11127","type":"journal-article","created":{"date-parts":[[2012,2,28]],"date-time":"2012-02-28T15:02:00Z","timestamp":1330441320000},"page":"230-234","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Abnormal gyration of the temporal lobe and megalencephaly are typical features of thanatophoric dysplasia and can be visualized prenatally by ultrasound"],"prefix":"10.1002","volume":"40","author":[{"given":"H.\u2010G. K.","family":"Blaas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Vogt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. H.","family":"Eik\u2010Nes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,6,22]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10024-004-7084-0"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.4053"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.23.4.328"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.21.1.23"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/014436100434857"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-005-1059-8"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.33909"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7062"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.08.1524"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-010-1697-4"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1996.08010042.x"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.3909"},{"key":"e_1_2_4_14_2","first-page":"435","article-title":"Une malformation c\u00e9r\u00e9brale particuliere associ\u00e9e au nanisme thanatophore","volume":"125","author":"Gouti\u00e8res F","year":"1971","journal-title":"Rev Neurol"},{"key":"e_1_2_4_15_2","first-page":"132","article-title":"Neuropathological findings in thanatophoric dysplasia","volume":"107","author":"Wongmongkolrit T","year":"1983","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_4_16_2","doi-asserted-by":"publisher","DOI":"10.1159\/000120384"},{"key":"e_1_2_4_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1789.2001.00386.x"},{"key":"e_1_2_4_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2005.02.003"},{"key":"e_1_2_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2005.03.001"},{"key":"e_1_2_4_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2007.05835.x"},{"key":"e_1_2_4_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320280521"},{"key":"e_1_2_4_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19980707)78:3<274::AID-AJMG14>3.0.CO;2-C"},{"key":"e_1_2_4_23_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1681.2001.03477.x"},{"key":"e_1_2_4_24_2","doi-asserted-by":"publisher","DOI":"10.1186\/1749-8104-4-4"},{"key":"e_1_2_4_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.30974"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.11127","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.11127","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T08:49:52Z","timestamp":1696668592000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.11127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,22]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["10.1002\/uog.11127"],"URL":"https:\/\/doi.org\/10.1002\/uog.11127","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,22]]},"assertion":[{"value":"2012-01-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-06-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}