{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:55:20Z","timestamp":1786978520130,"version":"build-2736575974"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,7,27]],"date-time":"2004-07-27T00:00:00Z","timestamp":1090886400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2004,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the contribution of new imaging techniques in the prenatal diagnosis of skeletal dysplasia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Between May and October 2003, a prospective study was conducted in a single referral center. Three\u2010dimensional ultrasound (3D\u2010US) and three\u2010dimensional helical computer tomography (3D\u2010HCT) were performed after two\u2010dimensional ultrasound (2D\u2010US) in six cases of skeletal dysplasia. Diagnostic accuracy and detailed findings with each of the three techniques were compared with postnatal radiological findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were three cases of achondroplasia, two cases of osteogenesis imperfecta type II and one case of chondrodysplasia punctata. Termination of pregnancy was performed in five cases and one fetus with osteogenesis imperfecta type II was delivered at term by Cesarean section. 2D\u2010US made the correct diagnosis in four cases. 3D\u2010US and 3D\u2010HCT achieved an accurate diagnosis in all six cases. 3D\u2010HCT and 3D\u2010US identified significantly more abnormalities than did 2D\u2010US (3D\u2010HCT: 94.3% (33\/35); 3D\u2010US: 77.1% (27\/35); 2D\u2010US: 51.4% (18\/35);\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.01). The diagnosis was made between 27 and 36 weeks' gestation in all cases. The advantage of 3D\u2010HCT over 3D\u2010US was the possibility of imaging the entire fetus.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>3D\u2010US and 3D\u2010HCT seem to be useful complementary methods to 2D\u2010US, and may improve accuracy of the prenatal diagnosis of skeletal disorders. These new imaging technologies may have a role in the prenatal multidisciplinary approach to the diagnosis of skeletal dysplasias. Copyright \u00a9 2004 ISUOG. Published by John Wiley &amp; Sons, Ltd.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/uog.1113","type":"journal-article","created":{"date-parts":[[2004,7,27]],"date-time":"2004-07-27T07:00:56Z","timestamp":1090911656000},"page":"134-140","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":127,"title":["Prenatal diagnosis of fetal skeletal dysplasias by combining two\u2010dimensional and three\u2010dimensional ultrasound and intrauterine three\u2010dimensional helical computer tomography"],"prefix":"10.1002","volume":"24","author":[{"given":"R.","family":"Ruano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Molho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Roume","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Ville","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,7,27]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"105","article-title":"Bone dysplasias: an introduction","volume":"49","author":"Azouz EM","year":"1998","journal-title":"Can Assoc Radiol J"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0095-5108(05)70060-9"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/01241398-200009000-00009"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-3995(00)01026-1"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2003.22.3.255"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.214.3.r00mr23717"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.111"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199707)17:7<670::AID-PD113>3.0.CO;2-8"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.172.3.10063887"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0223(200101)21:1<68::AID-PD994>3.0.CO;2-3"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0223(200102)21:2<89::AID-PD21>3.0.CO;2-9"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/1096-8628(20010115)98:2<117::AID-AJMG1018>3.0.CO;2-R"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0960-7692.2001.00496.x"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2001.20.6.699"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002470100017"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02723787"},{"key":"e_1_2_5_18_2","first-page":"685","article-title":"Vade\u2010mecum du scanner h\u00e9lico\u00efdal: estimation des doses, choix des param\u00e8tres","volume":"83","author":"Cordoliani YS","year":"2002","journal-title":"J Radiol"},{"key":"e_1_2_5_19_2","first-page":"1027","article-title":"La scanopelvimetrie spiral\u00e9e: les advantages de technique d'acquisition volumetrique peu irradi\u00e9e","volume":"84","author":"Breidt D","year":"2003","journal-title":"J Radiol"},{"key":"e_1_2_5_20_2","first-page":"595","article-title":"[Pregnancy and medical radiation: to demystify and take the drama out of managing]","volume":"83","author":"Cordoliani YS","year":"2002","journal-title":"J Radiol"}],"container-title":["Ultrasound in Obstetrics &amp; 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