{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T10:37:13Z","timestamp":1788863833141,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,11,29]],"date-time":"2012-11-29T00:00:00Z","timestamp":1354147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the degree of compensatory enlargement, and its time of onset, of the solitary functioning kidney (<jats:styled-content style=\"fixed-case\">SFK<\/jats:styled-content>) in fetuses with unilateral renal agenesis (<jats:styled-content style=\"fixed-case\">URA<\/jats:styled-content>) or unilateral multicystic kidney dysplasia (<jats:styled-content style=\"fixed-case\">MCKD<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>methods<\/jats:title><jats:p>This was a retrospective study of fetuses with  <jats:styled-content style=\"fixed-case\">URA<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">MCKD<\/jats:styled-content> diagnosed prenatally and confirmed postnatally in the period from January 1999 to May 2011. Fetuses with any other congenital anomalies were excluded. Measurements of kidney length were retrieved from our prenatal ultrasound database and a nomogram was established and compared with that for normal kidney length.<\/jats:p><\/jats:sec><jats:sec><jats:title>results<\/jats:title><jats:p>In total, 67 fetuses were identified, 60 with <jats:styled-content style=\"fixed-case\">MCKD<\/jats:styled-content> and seven with <jats:styled-content style=\"fixed-case\">URA<\/jats:styled-content>, for which we obtained 147 kidney length measurements from our database. Mean gestational age at time of measurement was 29.7 (range, 18.4\u201336.7) weeks. Compensatory enlargement, defined as renal length &gt;95<jats:sup>th<\/jats:sup> percentile for gestational age, was demonstrated in 87% of the <jats:styled-content style=\"fixed-case\">MCKD<\/jats:styled-content> cases and 100% of the <jats:styled-content style=\"fixed-case\">URA<\/jats:styled-content> cases (88% of cases overall). We estimated the mean enlargement for an <jats:styled-content style=\"fixed-case\">SFK<\/jats:styled-content> (defined as difference from 50<jats:sup>th<\/jats:sup> percentile for normal renal length) at 36 weeks' gestation to be 23.1% (9.25 mm), with the mean value being 11.4% (5.04 mm) greater than the 95<jats:sup>th<\/jats:sup> percentile for a normal kidney at this gestational age. Compensatory enlargement of <jats:styled-content style=\"fixed-case\">SFKs<\/jats:styled-content> was evident from the 20<jats:sup>th<\/jats:sup> week of gestation onwards.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Compensatory enlargement of <jats:styled-content style=\"fixed-case\">SFKs<\/jats:styled-content> occurs in almost 90% of fetuses with <jats:styled-content style=\"fixed-case\">MCKD<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">URA<\/jats:styled-content>, and may be observed from the 20<jats:sup>th<\/jats:sup> week of gestation onwards.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.11168","type":"journal-article","created":{"date-parts":[[2012,5,14]],"date-time":"2012-05-14T08:42:38Z","timestamp":1336984958000},"page":"665-668","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Compensatory enlargement of a solitary functioning kidney during fetal development"],"prefix":"10.1002","volume":"40","author":[{"given":"S. H.","family":"van Vuuren","sequence":"first","affiliation":[{"name":"Department of Pathology University Medical Centre Utrecht  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"van der Doef","sequence":"additional","affiliation":[{"name":"Department of Obstetrics University Medical Centre Utrecht  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. E.","family":"Cohen\u2010Overbeek","sequence":"additional","affiliation":[{"name":"Department of Prenatal Medicine Erasmus MC, University Medical Centre  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Goldschmeding","sequence":"additional","affiliation":[{"name":"Department of Pathology University Medical Centre Utrecht  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. R.","family":"Pistorius","sequence":"additional","affiliation":[{"name":"Department of Obstetrics University Medical Centre Utrecht  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. P. V. M.","family":"de Jong","sequence":"additional","affiliation":[{"name":"Department of Paediatric Urology University Children's Hospitals UMC Utrecht and AMC Amsterdam  Utrecht and Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,11,29]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"103","article-title":"Mechanisms of the early and late response of the kidney to contralateral nephrectomy","volume":"14","author":"Shohat J","year":"1991","journal-title":"Ren Physiol Biochem"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1981.241.1.F85"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/1.4.335"},{"key":"e_1_2_5_5_1","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1681\/ASN.V132406","article-title":"Compensatory renal growth after unilateral nephrectomy in the ovine fetus","volume":"13","author":"Douglas\u2010Denton R","year":"2002","journal-title":"J Am Soc Nephrol"},{"key":"e_1_2_5_6_1","first-page":"275","article-title":"Focal and segmental glomerulosclerosis and porteinuria associated with unilateral renal agenesis","volume":"46","author":"Kiprov DD","year":"1982","journal-title":"Lab Invest"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198405243102101"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2006.06504.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfn777"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020549"},{"key":"e_1_2_5_11_1","first-page":"S124","article-title":"Nephron mass as a risk factor for progression of renal disease","volume":"63","author":"Brenner BM","year":"1997","journal-title":"Kidney Int Suppl"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-005-1914-9"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-004-1549-2"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2002.00322.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420440103"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)35614-8"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.11169"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.189.3.8234697"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2000.00064.x"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.1851"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-010-1746-0"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.693"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1992.tb13726.x"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.2008.01315.x"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.11168","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.11168","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T20:36:16Z","timestamp":1697402176000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.11168"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,29]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["10.1002\/uog.11168"],"URL":"https:\/\/doi.org\/10.1002\/uog.11168","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,29]]},"assertion":[{"value":"2012-03-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-11-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}