{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T19:07:53Z","timestamp":1780340873772,"version":"3.54.1"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,3,4]],"date-time":"2013-03-04T00:00:00Z","timestamp":1362355200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the prognostic value of a hernia sac in isolated congenital diaphragmatic hernia (<jats:styled-content style=\"fixed-case\">CDH<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Our database was searched to identify all consecutive cases of <jats:styled-content style=\"fixed-case\">CDH<\/jats:styled-content> referred to our fetal medicine unit between January 2004 and August 2011. Presence or absence of a hernia sac was assessed in liveborn cases using surgery or postnatal autopsy reports. We studied the correlation between the presence of a hernia sac and prenatal findings and perinatal  morbidity and mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Over the study period, there were 70 cases with isolated <jats:styled-content style=\"fixed-case\">CDH<\/jats:styled-content> born alive in which either a surgery or autopsy report was available. Neonatal death, either preoperative or postoperative, occurred in 1\/18 (5.6%) infants with a hernia sac and in 17\/52 (32.7%) cases without a hernia sac\n(<jats:italic>P<\/jats:italic>\u2009=\u20090.03). Patients with a hernia sac had a significantly higher observed to expected pulmonary volume on prenatal magnetic resonance imaging (51.9 vs 39.3%, <jats:italic>P<\/jats:italic>\u2009=\u20090.01). Neonatal morbidity in surviving infants was lower in the group with a hernia sac, although not significantly.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The presence of a hernia sac is associated with a higher pulmonary volume and a better overall prognosis for <jats:styled-content style=\"fixed-case\">CDH<\/jats:styled-content>. Copyright \u00a9 2012 ISUOG. 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