{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:14:42Z","timestamp":1791929682371,"version":"4.3.4"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,1,7]],"date-time":"2013-01-07T00:00:00Z","timestamp":1357516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To review the anomaly spectrum of prenatally detected absent pulmonary valve syndrome (<jats:styled-content style=\"fixed-case\">APVS<\/jats:styled-content>) and the outcome after diagnosis. Previous fetal studies reported survival rates of \u2264\u200925% for patients with intended postnatal care.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical data and echocardiograms of 12 cases with a fetal diagnosis of <jats:styled-content style=\"fixed-case\">APVS<\/jats:styled-content> between 2000 and 2010 were analyzed in this retrospective single\u2010center study. Collected parameters included: gestational age at referral, associated fetal abnormalities, cardiothoracic ratio, maximum diameters of pulmonary annulus and main and branch pulmonary arteries, ventricular dimensions and function as well as ventricular Doppler flows. Karyotyping included fluorescence <jats:italic>in\u2010situ<\/jats:italic> hybridization (<jats:styled-content style=\"fixed-case\">FISH<\/jats:styled-content>) analysis for microdeletion 22q11.2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median gestational age at diagnosis was 24 weeks. Three subtypes of <jats:styled-content style=\"fixed-case\">APVS<\/jats:styled-content> were observed: (1) with tetralogy of Fallot (<jats:styled-content style=\"fixed-case\">TOF<\/jats:styled-content>) and no arterial duct (<jats:italic>n<\/jats:italic>\u2009=\u200910; 83%); (2) isolated, with a large arterial duct (<jats:italic>n<\/jats:italic>\u2009=\u20091; 8%); and (3) with tricuspid atresia, right ventricular dysplasia and a restricted duct (<jats:italic>n<\/jats:italic>\u2009=\u20091; 8%). The cardiothoracic ratio and pulmonary artery dimensions were increased in all cases. The karyotype was abnormal in 70% of fetuses with <jats:styled-content style=\"fixed-case\">TOF<\/jats:styled-content> and their mortality rate was significantly higher due to pregnancy termination (<jats:italic>n<\/jats:italic>\u2009=\u20093) or perinatal demise (<jats:italic>n<\/jats:italic>\u2009=\u20092) (hazard ratio, 5; 95%\u2009<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 0.87\u221228.9; <jats:italic>P<\/jats:italic>\u2009=\u20090.015). Of seven live births with active postnatal care, six children (86%) were alive without residual respiratory symptoms at a median follow\u2010up of 4.7 (range, 2.1\u221210.6) years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Outcome after fetal diagnosis of <jats:styled-content style=\"fixed-case\">APVS<\/jats:styled-content> was significantly better in this study compared with those of previous fetal series, with a low mortality rate for actively managed patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.11193","type":"journal-article","created":{"date-parts":[[2012,5,17]],"date-time":"2012-05-17T19:13:19Z","timestamp":1337281999000},"page":"162-167","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["Prenatal diagnosis and outcome of absent pulmonary valve syndrome: contemporary single\u2010center experience and review of the literature"],"prefix":"10.1002","volume":"41","author":[{"given":"D.","family":"Wertaschnigg","sequence":"first","affiliation":[{"name":"Fetal Cardiac Program, Labatt Family Heart Centre, Department of Pediatrics, The Hospital for Sick Children University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Jaeggi","sequence":"additional","affiliation":[{"name":"Fetal Cardiac Program, Labatt Family Heart Centre, Department of Pediatrics, The Hospital for Sick Children University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Chitayat","sequence":"additional","affiliation":[{"name":"Prenatal Diagnosis and Medical Genetics Program, Mount Sinai Hospital University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Shannon","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Mount Sinai Hospital University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Ryan","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit, Mount Sinai Hospital University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Mount Sinai Hospital University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. J.","family":"Yoo","sequence":"additional","affiliation":[{"name":"Fetal Cardiac Program, Labatt Family Heart Centre, Department of Pediatrics, The Hospital for Sick Children University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Jaeggi","sequence":"additional","affiliation":[{"name":"Fetal Cardiac Program, Labatt Family Heart Centre, Department of Pediatrics, The Hospital for Sick Children University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,1,7]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.1729"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.2807"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(90)90598-U"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2004.23.3.417"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004310050959"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8175.2002.00489.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7500"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(02)03238-1"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(84)90933-0"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2006.05.049"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(89)90442-6"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2001.00242.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2010.29.5.823"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.65.1_Spec_No.20"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(92)90300-N"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2000.00082.x"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0029-7844(94)00328-B"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.2597"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2008.02.006"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(76)90290-3"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(02)02326-3"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951104004093"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(02)04297-2"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s100249910050"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.11193","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.11193","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/uog.11193","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.11193","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T18:10:29Z","timestamp":1692987029000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.11193"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,7]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["10.1002\/uog.11193"],"URL":"https:\/\/doi.org\/10.1002\/uog.11193","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,7]]},"assertion":[{"value":"2012-05-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-01-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}