{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T05:14:04Z","timestamp":1761110044122},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,6,24]],"date-time":"2013-06-24T00:00:00Z","timestamp":1372032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p><jats:italic>To investigate, using three\u2010dimensional power Doppler ultrasound (<jats:styled-content style=\"fixed-case\">3D\u2010PDU<\/jats:styled-content>), alterations in cervical intratumoral vascularization during and after radiotherapy<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:italic>Between 2004 and 2009 we enrolled into the study 37 patients with FIGO Stages <jats:styled-content style=\"fixed-case\">IB1\u2013IIB<\/jats:styled-content> cervical carcinoma who were undergoing radiotherapy. Serial <jats:styled-content style=\"fixed-case\">3D\u2010PDU<\/jats:styled-content> scans were performed during treatment, providing ultrasonographic measurement of tumor size, vascularization index, flow index and vascularization flow index, as well as monthly for 3 months post\u2010treatment and tri\u2010monthly thereafter, until vascularity was undetectable on two consecutive occasions. Physical examination, cervical cytology and serum marker evaluation were performed every 3\u20136 months for the first 5 years following treatment. Patients evaluated after a 2\u2010year tumor\u2010free interval and those with clinically assessed positive findings at follow\u2010up underwent <jats:styled-content style=\"fixed-case\">3D\u2010PDU<\/jats:styled-content> to detect possible local disease<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>A total of 329 <jats:styled-content style=\"fixed-case\">3D\u2010PDU<\/jats:styled-content> scans were performed in the 37 women. Cervical tumors and intratumoral vascularization disappeared within 3 months following radiotherapy, except in one patient with persistent disease. Nine patients had disease relapse, in four of whom the recurrence was local. In three of these four, there was recurrence of tumor and vascularization after a complete response. At follow\u2010up, <jats:styled-content style=\"fixed-case\">3D\u2010PDU<\/jats:styled-content> detected local disease with 75.0% sensitivity and 98.5% specificity, while serum markers detected local disease among 34 patients with squamous cell carcinoma with 20.0% sensitivity and 77.3% specificity<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:italic>Compared with serum markers in cervical squamous cell carcinoma, <jats:styled-content style=\"fixed-case\">3D\u2010PDU<\/jats:styled-content> has higher sensitivity and specificity for detecting local recurrence or persistence in cervical carcinoma. Thus, <jats:styled-content style=\"fixed-case\">3D\u2010PDU<\/jats:styled-content> combined with clinical assessment may be a new and safe method for monitoring radiotherapy treatment response and detecting local recurrence. Copyright \u00a9 2013 ISUOG. Published by John Wiley &amp; Sons Ltd<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.11223","type":"journal-article","created":{"date-parts":[[2012,6,29]],"date-time":"2012-06-29T10:49:24Z","timestamp":1340966964000},"page":"84-92","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Three\u2010dimensional power Doppler ultrasound in cervical carcinoma: monitoring treatment response to radiotherapy"],"prefix":"10.1002","volume":"42","author":[{"given":"Y.\u2010F.","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology, National Cheng Kung University Hospital, College of Medicine National Cheng Kung University  Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.\u2010M.","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology, National Cheng Kung University Hospital, College of Medicine National Cheng Kung University  Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.\u2010P.","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology, National Cheng Kung University Hospital, College of Medicine National Cheng Kung University  Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. H. W.","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, National Cheng Kung University Hospital, College of Medicine National Cheng Kung University  Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.\u2010F.","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology, National Cheng Kung University Hospital, College of Medicine National Cheng Kung University  Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.\u2010H.","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, National Cheng Kung University Hospital, College of Medicine National Cheng Kung University  Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.\u2010Y.","family":"Chou","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology, National Cheng Kung University Hospital, College of Medicine National Cheng Kung University  Tainan Taiwan"},{"name":"Cancer Center National Cheng Kung University Hospital  Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,6,24]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"The NCCN Clinical Practice Guidelines in Oncology\u2122 Cervical Cancer (Version 1.2011). National Comprehensive Cancer Network Inc. 2011. http:\/\/www.nccn.org\/professionals\/physician_gls\/f_guidelines.asp. [Accessed 15 December 2011]."},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.03.008"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/IGC.0b013e31819c9ffd"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2007.09.002"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1438.2003.13302.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19950515)75:10<2518::AID-CNCR2820751018>3.0.CO;2-A"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1999.tb08138.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1999.14020139.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2010.10.023"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.1703"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.2001.6253"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2001.20.8.829"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1997.4714"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.1756"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/IGC.0b013e3181d159f9"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2005.01.012"},{"key":"e_1_2_6_18_1","first-page":"10","article-title":"Impact of three\u2010dimensional (3D) ultrasonography and power Doppler angiography in the management of cervical cancer","volume":"31","author":"Tanaka K","year":"2010","journal-title":"Eur J Gynaecol Oncol"},{"key":"e_1_2_6_19_1","volume-title":"Annual Report on the Results of Treatment in Gynecological Cancer","author":"Pettersson F","year":"1985"},{"key":"e_1_2_6_20_1","first-page":"260","volume-title":"Tumor of the Breast and Female Genital Organs","author":"Wells M","year":"2003"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.3.205"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2010.09.043"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1159\/000152943"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1438.2007.00878.x"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/IGC.0b013e3181d5c27a"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7638"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.11223","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.11223","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T21:12:07Z","timestamp":1696367527000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.11223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,24]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["10.1002\/uog.11223"],"URL":"https:\/\/doi.org\/10.1002\/uog.11223","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,24]]},"assertion":[{"value":"2012-05-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-06-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}