{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:58:18Z","timestamp":1791237498787,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,3,25]],"date-time":"2013-03-25T00:00:00Z","timestamp":1364169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate differences in tissue characterization using three\u2010dimensional sonographic mean gray value (MGV) between retrocervical and rectosigmoid deeply infiltrating endometriosis, and to assess intra\u2010 and interobserver concordance in MGV quantification.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this retrospective study, stored ultrasound volumes from  50 premenopausal women (mean age, 32\u2009years) with 57 histologically confirmed nodules of deep endometriosis were retrieved from our database for analysis. A single experienced operator had acquired all volumes. For each nodule, the <jats:styled-content style=\"fixed-case\">MGV<\/jats:styled-content> was evaluated using Virtual Organ Computer\u2010aided <jats:styled-content style=\"fixed-case\">AnaLysis<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">VOCAL<\/jats:styled-content>) software with semiautomated sphere\u2010sampling (1\u2009cm<jats:sup>3<\/jats:sup>) from the central part of the nodule. In these patients the <jats:styled-content style=\"fixed-case\">MGV<\/jats:styled-content> was also quantified from the myometrium of the fundal part of the uterus. In addition, two observers calculated the <jats:styled-content style=\"fixed-case\">MGV<\/jats:styled-content> in a subset of 24 volumes in order to quantify inter\u2010 and intraobserver agreement using intraclass correlation coefficients (<jats:styled-content style=\"fixed-case\">ICC<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean <jats:styled-content style=\"fixed-case\">MGV<\/jats:styled-content> was significantly higher in rectosigmoid nodules (<jats:italic>n<\/jats:italic>\u2009=\u200934) than in nodules with a retrocervical location (<jats:italic>n<\/jats:italic>\u2009=\u200923) (23.863 vs 17.705; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). <jats:styled-content style=\"fixed-case\">MGV<\/jats:styled-content> of the myometrium was significantly higher in comparison with that of nodules in both locations (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001 for both). Intra\u2010 and interobserver measurement reproducibility was excellent (<jats:styled-content style=\"fixed-case\">ICC<\/jats:styled-content>\u2009&gt;\u20090.95).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Retrocervical and rectosigmoid endometriotic nodules display significantly different MGVs. Measurement of MGV is highly reproducible and its clinical value in the diagnosis and assessment of distribution of deep endometriosis should be assessed in future studies. Copyright \u00a9 2012 ISUOG. Published by John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.12292","type":"journal-article","created":{"date-parts":[[2012,8,23]],"date-time":"2012-08-23T10:05:11Z","timestamp":1345716311000},"page":"459-464","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Tissue characterization using mean gray value analysis in deep infiltrating endometriosis"],"prefix":"10.1002","volume":"41","author":[{"given":"S.","family":"Guerriero","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology Azienda Ospedaliero Universitaria di Cagliari  Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Pilloni","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Azienda Ospedaliero Universitaria di Cagliari  Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. L.","family":"Alcazar","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Cl\u00ednica Universidad de Navarra University of Navarra  Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Sedda","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Azienda Ospedaliero Universitaria di Cagliari  Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Ajossa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Azienda Ospedaliero Universitaria di Cagliari  Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Mais","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Azienda Ospedaliero Universitaria di Cagliari  Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. 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