{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T17:43:51Z","timestamp":1785347031309,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,4,11]],"date-time":"2013-04-11T00:00:00Z","timestamp":1365638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To construct reference ranges for cisterna magna (<jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content>) width at 11\u201313 weeks' gestation in healthy fetuses and determine whether open spina bifida and posterior fossa anomalies could be diagnosed in the first trimester.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective study. <jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content> width reference ranges were constructed based on the measurements obtained from 80 healthy fetuses with normal postnatal outcome undergoing routine first\u2010trimester ultrasound at 11\u201313 weeks, using the Lambda\u2010Mu\u2010Sigma method. <jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content> was measured in the fetal mid\u2010sagittal view, as routinely used for nuchal translucency assessment. In addition, first\u2010trimester ultrasound images in 11 fetuses with open spina bifida or posterior fossa anomalies, most of which were diagnosed later in pregnancy, were retrospectively reviewed, and <jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content> measurements were compared against reference ranges.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content> width was noted to increase with gestational age in normal fetuses. The anomalies in the 11 fetuses we reviewed were: open spina bifida (<jats:italic>n<\/jats:italic>\u2009=\u20095), megacisterna magna (<jats:italic>n<\/jats:italic>\u2009=\u20093), Blake's pouch cyst (<jats:italic>n<\/jats:italic>\u2009=\u20092) and posterior fossa arachnoid cyst (<jats:italic>n<\/jats:italic>\u2009=\u20091). All fetuses with open spina bifida had a <jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content> width below the 5<jats:sup>th<\/jats:sup> percentile. In the two fetuses with Blake's pouch cyst and in two with megacisterna magna, <jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content> width was above the 95<jats:sup>th<\/jats:sup> percentile. In one of the fetuses with a megacisterna magna and the one with an arachnoid cyst, <jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content> width was within normal range.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We have constructed reference ranges for <jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content> width at 11\u201313 weeks using the mid\u2010sagittal view. It appears that first\u2010trimester <jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content> width can be used as a marker for the early detection of open spina bifida. However, our findings need to be confirmed in prospective large series. Copyright \u00a9 2012 ISUOG. Published by John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.12302","type":"journal-article","created":{"date-parts":[[2012,9,18]],"date-time":"2012-09-18T14:49:14Z","timestamp":1347979754000},"page":"515-520","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Cisterna magna width at 11\u201313 weeks in the detection of posterior fossa anomalies"],"prefix":"10.1002","volume":"41","author":[{"given":"R.","family":"Garcia\u2010Posada","sequence":"first","affiliation":[{"name":"Maternal\u2013Fetal Department, Institute of Gynecology, Obstetrics and Neonatology, IDIBAPS (Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer), Hospital Clinic University of Barcelona Medical School, Barcelona  Catalonia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Eixarch","sequence":"additional","affiliation":[{"name":"Maternal\u2013Fetal Department, Institute of Gynecology, Obstetrics and Neonatology, IDIBAPS (Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer), Hospital Clinic University of Barcelona Medical School, Barcelona  Catalonia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Sanz","sequence":"additional","affiliation":[{"name":"Maternal\u2013Fetal Department, Institute of Gynecology, Obstetrics and Neonatology, IDIBAPS (Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer), Hospital Clinic University of Barcelona Medical School, Barcelona  Catalonia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Puerto","sequence":"additional","affiliation":[{"name":"Maternal\u2013Fetal Department, Institute of Gynecology, Obstetrics and Neonatology, IDIBAPS (Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer), Hospital Clinic University of Barcelona Medical School, Barcelona  Catalonia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Figueras","sequence":"additional","affiliation":[{"name":"Maternal\u2013Fetal Department, Institute of Gynecology, Obstetrics and Neonatology, IDIBAPS (Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer), Hospital Clinic University of Barcelona Medical School, Barcelona  Catalonia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Borrell","sequence":"additional","affiliation":[{"name":"Maternal\u2013Fetal Department, Institute of Gynecology, Obstetrics and Neonatology, IDIBAPS (Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer), Hospital Clinic University of Barcelona Medical School, Barcelona  Catalonia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,4,11]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.3909"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.sult.2011.02.003"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1999.13010071.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.10070"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2642"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.10111"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7329"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7552"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.10088"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2632"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.9067"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.8957"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2869"},{"key":"e_1_2_5_15_1","unstructured":"Fetal Medicine Foundation. www.fetalmedicine.com\/fmf\/online\u2010education\/01\u201011\u2010136\u2010week\u2010scan\/."},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.8994"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.10118"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780111005"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(90)90378-K"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2832"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2011.30.12.1643"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00301017"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.11099"}],"container-title":["Ultrasound in Obstetrics &amp; 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