{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T01:42:58Z","timestamp":1793497378718,"version":"4.5.0"},"reference-count":54,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,11,29]],"date-time":"2012-11-29T00:00:00Z","timestamp":1354147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Measurement of endometrial thickness is an important tool in the assessment of women with postmenopausal bleeding, but the role of endometrial thickness measurement by ultrasound in asymptomatic women is unclear. The aims of this study were to determine: (1) the normal endometrial thickness measured by ultrasonography, (2) the prevalence of serious endometrial pathology and (3) the sensitivity and specificity of endometrial thickness measurement by transvaginal ultrasonography (<jats:styled-content style=\"fixed-case\">TVS<\/jats:styled-content>) for diagnosing premalignant and malignant endometrial disease in asymptomatic postmenopausal women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A MEDLINE and EMBASE search (from inception to January 2011) was performed. Articles reporting on endometrial thickness measurement in the diagnosis of endometrial carcinoma and atypical hyperplasia in asymptomatic postmenopausal women not using hormone replacement therapy (<jats:styled-content style=\"fixed-case\">HRT<\/jats:styled-content>) were selected. Endometrial thickness and the prevalence of endometrial (pre)malignancies were recorded. If possible, 2 \u00d7 2 tables were extracted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010two studies reporting on 11\u2009100 women were included. The estimated mean endometrial thickness was 2.9 mm (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 2.6\u20133.3 mm). The pooled estimated prevalences of endometrial carcinoma and atypical endometrial hyperplasia were 0.62% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 0.42\u20130.82%) and 0.59% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 0.22\u20130.96%), respectively. Summary estimates for sensitivity and specificity of <jats:styled-content style=\"fixed-case\">TVS<\/jats:styled-content> endometrial thickness measurement in the prediction of endometrial carcinoma were 0.83 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 0.19\u20131.00) and 0.72 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 0.23\u20130.95) for a 5\u2010mm cut\u2010off and 0.33 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 0.04\u20130.85) and 0.94 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 0.92\u20130.96) for a 6\u2010mm cut\u2010off.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results from this  systematic review do not justify the use of endometrial thickness as a screening test for endometrial carcinoma and atypical endometrial hyperplasia   in asymptomatic postmenopausal women not using <jats:styled-content style=\"fixed-case\">HRT<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.12306","type":"journal-article","created":{"date-parts":[[2012,9,24]],"date-time":"2012-09-24T08:57:11Z","timestamp":1348477031000},"page":"621-629","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":89,"title":["Capacity of endometrial thickness measurement to diagnose endometrial carcinoma in asymptomatic postmenopausal women: a systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"40","author":[{"given":"M. C.","family":"Breijer","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Academic Medical Center  Amsterdam The Netherlands"},{"name":"Department of Obstetrics and Gynecology Albert Schweitzer Hospital  Dordrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. A. H.","family":"Peeters","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Maxima Medical Center  Veldhoven The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. C.","family":"Opmeer","sequence":"additional","affiliation":[{"name":"Clinical Research Unit Academic Medical Center  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. J.","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Birmingham Women's Hospital  Edgbaston Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. H. M.","family":"Verheijen","sequence":"additional","affiliation":[{"name":"Department of Gynecological Oncology University Medical Center  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. W. J.","family":"Mol","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Academic Medical Center  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Timmermans","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Academic Medical Center  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,11,29]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(96)80082-2"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.1440"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.280.17.1510"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0412.2004.00357.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2001.20.10.1025"},{"key":"e_1_2_5_7_1","unstructured":"Dutch Society of Obstetrics and Gynaecology(NVOG).NVOG\u2010richtlijn Abnormaal vaginaal bloedverlies in de menopauze[In Dutch].NVOG Guideline: Abnormal vaginal bleeding during menopause. NVOG 2003."},{"key":"e_1_2_5_8_1","volume-title":"Investigation of postmenopausal bleeding","author":"Scottish Intercollegiate Guidelines Network","year":"2002"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.1704"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-3-25"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2005.02.022"},{"key":"e_1_2_5_12_1","first-page":"936","article-title":"Ultrasonic thickness of the endometrium correlated to body weight in asymptomatic postmenopausal women","volume":"82","author":"Andolf E","year":"1993","journal-title":"Obstet Gynecol"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1996.07050322.x"},{"key":"e_1_2_5_14_1","first-page":"373","article-title":"Postmenopausal endometrial cancer screening: is there a correlation between transvaginal sonographic measurement of endometrial thickness and body mass index?","volume":"25","author":"G\u00fcven MA","year":"2004","journal-title":"Eur J Gynaecol Oncol"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/13697137.2010.514079"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7292(95)02554-5"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000083089"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2000.00273.x"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1035751"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(93)90506-E"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2002.00828.x"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(97)00111-2"},{"key":"e_1_2_5_23_1","first-page":"179","article-title":"Thin\u2010layer cytology in endometrial diagnosis","volume":"95","author":"Buccoliero AM","year":"2003","journal-title":"Pathologica"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042192-199906010-00013"},{"key":"e_1_2_5_25_1","first-page":"26","article-title":"Correlation of vaginal ultrasound and hysteroscopy with endometrial histopathology in postmenopausal women","volume":"6","author":"Elewa AM","year":"2001","journal-title":"Middle East Fertility Soc J"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/gye.15.1.63.67"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0104-42302007000400021"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199712183372502"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7292(93)90375-7"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-3804(00)80040-7"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5122(03)00160-9"},{"key":"e_1_2_5_32_1","first-page":"2517","article-title":"Screening transvaginal uterine ultrasonography for identifying endometrial pathology in postmenopausal women","volume":"22","author":"Paraskevaidis E","year":"2002","journal-title":"Anticancer Res"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1997.4699"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1159\/000087375"},{"issue":"12","key":"e_1_2_5_35_1","article-title":"Endometrial evaluation in asymptomatic postmenopausal women by transvaginal sonography and color flow Doppler","volume":"3","author":"Exacoustos C","year":"1996","journal-title":"J Am Assoc Gynecol Laparosc"},{"key":"e_1_2_5_36_1","first-page":"398","article-title":"Endometrial alterations on ultrasonography in asymptomatic postmenopausal women","volume":"51","author":"Parra JF","year":"2008","journal-title":"Progresos de Obstetricia y Ginecolog\u00eda"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2001.111088"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042192-199805040-00007"},{"issue":"112","key":"e_1_2_5_39_1","article-title":"Transvaginal sonographic prognostic value to detect endometrial pathology in postmenopausal asymptomatic women without hormone replacement therapy. Abstracts of the 58th Congress of the German Society of Gynecology and Obstetrics. October 5\u20138, 2010. Munich, Germany","volume":"282","author":"Psillaki AN I","year":"2010","journal-title":"Arch Gynecol Obstet"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1516-31802007000600007"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-1999-14181"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10397-005-0128-2"},{"key":"e_1_2_5_43_1","first-page":"339","article-title":"Transvaginal sonography as a screening method for the identification of patients at risk of postmenopausal endometrial pathology","volume":"45","author":"Zacchi V","year":"1993","journal-title":"Minerva Ginecol"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/0029-7844(95)00450-5"},{"key":"e_1_2_5_45_1","first-page":"237","article-title":"An audit of true prevalence of intra\u2010uterine pathology: The hysteroscopical findings controlled for patient selection in 1202 patients with abnormal uterine bleeding","volume":"4","author":"Emanuel MH","year":"1995","journal-title":"Gynaecol Endosc"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.323.7305.157"},{"key":"e_1_2_5_47_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-149-12-200812160-00008"},{"issue":"1","key":"e_1_2_5_48_1","first-page":"S37","article-title":"Issues in combining independent estimates of the sensitivity and specificity of a diagnostic test","volume":"2","author":"Shapiro DE","year":"1995","journal-title":"Acad Radiol"},{"key":"e_1_2_5_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(00)00356-7"},{"key":"e_1_2_5_50_1","first-page":"611","article-title":"Diabetes and endometrial cancer in the Iowa women's health study","volume":"10","author":"Anderson KE","year":"2001","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_5_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a008707"},{"key":"e_1_2_5_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2007.01424.x"},{"key":"e_1_2_5_53_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000136080.55874.7f"},{"key":"e_1_2_5_54_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008946825313"},{"key":"e_1_2_5_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.11598"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.12306","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.12306","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T20:37:12Z","timestamp":1697402232000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.12306"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,29]]},"references-count":54,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["10.1002\/uog.12306"],"URL":"https:\/\/doi.org\/10.1002\/uog.12306","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,29]]},"assertion":[{"value":"2012-09-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-11-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}