{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T01:22:48Z","timestamp":1788916968960,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,1,31]],"date-time":"2013-01-31T00:00:00Z","timestamp":1359590400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To examine whether intrauterine growth restriction (<jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content>) is associated with increased cardiovascular risk later in life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We examined 19 young adults (aged 22\u201325 years) who were born at term after <jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content>, along with 18 controls. All had been examined previously with fetal Doppler, and in the present follow\u2010up with echocardiography, carotid echo\u2010tracking ultrasound, applanation tonometry, blood pressure and laser Doppler, in order to characterize their cardiac and vascular geometry and\/or function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The diameter of the ascending aorta and the left ventricular diameter were smaller in the <jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content> group, but only ascending aortic diameter remained significantly smaller after adjustment for body surface area (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). The aortic pressure augmentation index was higher in the <jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content> group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). The common carotid artery diameter, intima\u2013media thickness and distensibility as well as left ventricular mass and function were similar in the two groups. <jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content> status was found to be an independent predictor of ascending aortic diameter.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content> due to placental dysfunction seems to contribute to the higher systolic blood pressure augmentation and the smaller aortic dimensions that are observed in adults more than 20 years later, with possible negative consequences for future left ventricular performance due to increased aortic impedance.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.12314","type":"journal-article","created":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T09:40:06Z","timestamp":1349084406000},"page":"177-184","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Cardiovascular function in adulthood following intrauterine growth restriction with abnormal fetal blood flow"],"prefix":"10.1002","volume":"41","author":[{"given":"N.","family":"Bjarneg\u00e5rd","sequence":"first","affiliation":[{"name":"Department of Medical and Health Sciences Link\u00f6ping University  Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Morsing","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Clinical Sciences Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Cinthio","sequence":"additional","affiliation":[{"name":"Electrical Measurements, Faculty of Engineering LTH, Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"L\u00e4nne","sequence":"additional","affiliation":[{"name":"Department of Medical and Health Sciences Link\u00f6ping University  Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Brodszki","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Clinical Sciences Lund University  Lund 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