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A systematic literature search was performed to identify all reports of <jats:styled-content style=\"fixed-case\">ACC<\/jats:styled-content> and reference lists of articles were identified. <jats:styled-content style=\"fixed-case\">ACC<\/jats:styled-content> involves partial or complete absence of the main commissural pathway that connects the two cerebral hemispheres, and can be isolated (with no other abnormalities) or complex (coexisting with other abnormalities). It is a rare finding and the prevalence is difficult to estimate because of selection bias in reported series. The corpus callosum (<jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>) can be assessed on ultrasound by direct visualization, but indirect features, such as ventriculomegaly, absence of the cavum septi pellucidi or widening of interhemispheric fissure, are often the reason for detection in a screening population. Careful imaging in a center with a high level of expertise is required to make a full assessment and to exclude coexisting abnormalities, which occur in about 46% of fetuses. When available, magnetic resonance imaging appears to be an important adjunct as it allows direct visualization. It can reduce false\u2010positive rates on ultrasound and can confirm <jats:styled-content style=\"fixed-case\">ACC<\/jats:styled-content>, it can assess whether this is complete or partial and it can help in detecting coexisting brain abnormalities not seen on ultrasound. The overall rate of chromosomal abnormality in fetuses with <jats:styled-content style=\"fixed-case\">ACC<\/jats:styled-content> is 18%, but this high rate includes both isolated and complex <jats:styled-content style=\"fixed-case\">ACC<\/jats:styled-content>; more recent studies suggest that chromosomal abnormalities are rare in isolated cases. Nevertheless, postnatal follow\u2010up studies suggest that about 15% of cases thought to be isolated prenatally were found to have associated abnormalities after birth. Neurodevelopmental outcome in isolated <jats:styled-content style=\"fixed-case\">ACC<\/jats:styled-content> was recently reported in a systematic review and suggested normal outcome in about 65\u201375% of cases. Findings need to be considered in light of the several limitations of existing studies, in terms of study design, selection bias, varying definitions and imaging protocols, ascertainment bias and lack of control groups. These uncertainties mean that antenatal counseling is difficult and further large prospective studies are needed.<\/jats:p>","DOI":"10.1002\/uog.12315","type":"journal-article","created":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T09:40:18Z","timestamp":1349084418000},"page":"513-521","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":163,"title":["Counseling in fetal medicine: agenesis of the corpus callosum"],"prefix":"10.1002","volume":"40","author":[{"given":"S.","family":"Santo","sequence":"first","affiliation":[{"name":"Fetal Medicine Unit, Academic Department of Obstetrics and Gynaecology St George's, University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"D'Antonio","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit, Academic Department of Obstetrics and Gynaecology St George's, University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Homfray","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics St George's, University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Rich","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology St George's Healthcare NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Pilu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Bhide","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit, Academic Department of Obstetrics and Gynaecology St George's, University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Thilaganathan","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit, Academic Department of Obstetrics and Gynaecology St George's, University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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