{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T19:11:31Z","timestamp":1757704291587},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,12,14]],"date-time":"2012-12-14T00:00:00Z","timestamp":1355443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine the relationship between hematologic parameters at birth and prenatal progression of Doppler abnormalities in fetal growth restriction (<jats:styled-content style=\"fixed-case\">FGR<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study was a secondary analysis of <jats:styled-content style=\"fixed-case\">FGR<\/jats:styled-content> patients (abdominal circumference &lt; 5<jats:sup>th<\/jats:sup> percentile and umbilical artery pulsatility index (<jats:styled-content style=\"fixed-case\">UA\u2010PI<\/jats:styled-content>) elevation) with at least three examinations prior to delivery. Prenatal progression was classified as rapid, moderate or slow based on the interval between diagnosis and delivery and the extent of <jats:styled-content style=\"fixed-case\">UA<\/jats:styled-content>, middle cerebral artery and ductus venosus Doppler abnormalities. Associations between diagnosis\u2010to\u2010delivery interval, Doppler Z\u2010scores, progression and hematologic parameters at birth were examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 130 patients, 54 (41.5%) had rapid, 51 (39.2%) moderate and 25 (19.2%) slow deterioration, delivering within\u00a04,\u00a06\u00a0and\u00a09\u00a0weeks of diagnosis,\u00a0respectively. The strongest association of moderate and rapid deterioration was with a low platelet count (<jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.37 and 0.70, respectively; <jats:italic>P<\/jats:italic> &lt; 0.0001). In patients with moderate deterioration, platelet count correlated inversely with <jats:styled-content style=\"fixed-case\">UA\u2010PI<\/jats:styled-content> (\u03c1\u2009=\u2009\u22120.44, <jats:italic>P<\/jats:italic>\u2009=\u20090.001) and was lowest when end\u2010diastolic velocity was absent. With rapid progression, platelet count correlated inversely with nucleated red blood cell count (\u03c1\u2009=\u2009\u22120.51, <jats:italic>P<\/jats:italic> &lt; 0.001) but no longer with <jats:styled-content style=\"fixed-case\">UA\u2010PI<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our observations suggest a relationship between prenatal clinical progression of <jats:styled-content style=\"fixed-case\">FGR<\/jats:styled-content> and hematologic abnormalities at birth. Accelerating cardiovascular deterioration is associated with decreased platelet count, which can be explained by placental consumption or dysfunctional erythropoiesis and thrombopoiesis. Copyright \u00a9 2012 ISUOG. Published by John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.12322","type":"journal-article","created":{"date-parts":[[2012,10,15]],"date-time":"2012-10-15T09:48:20Z","timestamp":1350294500000},"page":"66-72","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Hematologic profile of neonates with growth restriction is associated with rate and degree of prenatal Doppler deterioration"],"prefix":"10.1002","volume":"41","author":[{"given":"A. A.","family":"Baschat","sequence":"first","affiliation":[{"name":"Department of Obstetrics, Gynecology &amp; Reproductive Sciences University of Maryland School of Medicine  Baltimore MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Kush","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology &amp; Reproductive Sciences University of Maryland School of Medicine  Baltimore MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Berg","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Prenatal Medicine Friedrich\u2010Wilhelm University  Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"Gembruch","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Prenatal Medicine Friedrich\u2010Wilhelm University  Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. H.","family":"Nicolaides","sequence":"additional","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine King's College Hospital  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. R.","family":"Harman","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology &amp; Reproductive Sciences University of Maryland School of Medicine  Baltimore MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O. 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