{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:43:03Z","timestamp":1787164983935,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,4,12]],"date-time":"2013-04-12T00:00:00Z","timestamp":1365724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2013,5]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objectives<\/jats:title>\n \n To examine whether embryonic volume (\n EV<\/jats:styled-content>\n ), as measured using three\u2010dimensional (\n 3D<\/jats:styled-content>\n ) ultrasound and a virtual reality approach, is a better measure of growth restriction than is crown\u2013rump length (\n CRL<\/jats:styled-content>\n ) in aneuploid fetuses.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We retrospectively measured\n CRL<\/jats:styled-content>\n and\n EV<\/jats:styled-content>\n in prospectively collected\n 3D<\/jats:styled-content>\n ultrasound volumes of 55 aneuploid fetuses using the Barco I\u2010Space\n VR<\/jats:styled-content>\n system. The gestational age ranged from 11\u2009+\u20092 to 14\u2009+\u20094 weeks. We compared our measured data with previously published reference curves for euploid fetuses. Delta\u2010values were calculated by subtracting the expected mean for euploid fetuses of the same gestational age from observed values. The one\u2010sample\n t<\/jats:italic>\n \u2010test was used to test the significance of differences observed.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The\n CRL<\/jats:styled-content>\n measurements of fetuses with trisomy 21 (\n n<\/jats:italic>\n \u2009=\u200926), trisomy 13 (\n n<\/jats:italic>\n \u2009=\u20095) and monosomy X (\n n<\/jats:italic>\n \u2009=\u20095) were comparable with those of euploid fetuses, but in fetuses with trisomy 18 (\n n<\/jats:italic>\n \u2009=\u200919) the\n CRL<\/jats:styled-content>\n was 14.5% smaller (\n P<\/jats:italic>\n \u2009<\u20090.001). The\n EV<\/jats:styled-content>\n in fetuses with trisomies 21, 18 and 13 and monosomy X was smaller than in euploid fetuses (\u201327.8%,\n P<\/jats:italic>\n \u2009<\u20090.001; \u201339.4%,\n P<\/jats:italic>\n \u2009<\u20090.001; \u201340.9%,\n P<\/jats:italic>\n \u2009=\u20090.004; and \u201327.3%,\n P<\/jats:italic>\n \u2009=\u20090.055, respectively).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n When relying on\n CRL<\/jats:styled-content>\n measurements alone, first\u2010trimester growth restriction is especially manifest in trisomy 18. Using\n EV<\/jats:styled-content>\n , growth restriction is also evident in trisomies 21 and 13 and monosomy X.\n EV<\/jats:styled-content>\n seems to be a more effective measurement for the assessment of first\u2010trimester growth restriction in aneuploid fetuses. Copyright \u00a9 2012 ISUOG. Published by John Wiley & Sons, Ltd.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/uog.12365","type":"journal-article","created":{"date-parts":[[2012,12,5]],"date-time":"2012-12-05T17:40:21Z","timestamp":1354729221000},"page":"521-525","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["First\u2010trimester crown\u2013rump length and embryonic volume of aneuploid fetuses measured in virtual reality"],"prefix":"10.1002","volume":"41","author":[{"given":"L.","family":"Baken","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Division of Obstetrics and Prenatal Medicine, Erasmus MC University Medical Centre Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. N. A. C. M.","family":"van Heesch","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Division of Obstetrics and Prenatal Medicine, Erasmus MC University Medical Centre Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. I. J.","family":"Wildschut","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Division of Obstetrics and Prenatal Medicine, Erasmus MC University Medical Centre Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. H. J.","family":"Koning","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics, Erasmus MC University Medical Centre Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. J.","family":"van der Spek","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics, Erasmus MC University Medical Centre Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. A. P.","family":"Steegers","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Division of Obstetrics and Prenatal Medicine, Erasmus MC University Medical Centre Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Exalto","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Division of Obstetrics and Prenatal Medicine, Erasmus MC University Medical Centre Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,4,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199702)17:2<155::AID-PD58>3.0.CO;2-1"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.03.090"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(97)70388-0"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deq175"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.1990"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2004.02.005"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.2794"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7348"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.10046"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.9074"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1145\/166117.166134"},{"key":"e_1_2_6_13_1","first-page":"136","article-title":"V\u2010scope: design and implementation of an immersive and desktop virtual reality volume visualization system","volume":"142","author":"Koning AH","year":"2009","journal-title":"Stud Health Technol Inform"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5343"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.2635"},{"issue":"90","key":"e_1_2_6_16_1","first-page":"e19","article-title":"Embryonic delay in growth and development related to confined placental trisomy 16 mosaicism, diagnosed by I\u2010Space Virtual Reality","volume":"2008","author":"Verwoerd\u2010Dikkeboom CM","year":"2017","journal-title":"Fertil Steril"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2008.02006.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5390"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deq061"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.34423"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1209227109"}],"container-title":["Ultrasound in Obstetrics & Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.12365","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.12365","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T00:03:22Z","timestamp":1697414602000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.12365"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,12]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["10.1002\/uog.12365"],"URL":"https:\/\/doi.org\/10.1002\/uog.12365","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,12]]},"assertion":[{"value":"2012-11-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-04-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}