{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T15:58:38Z","timestamp":1790351918609,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,7,26]],"date-time":"2013-07-26T00:00:00Z","timestamp":1374796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2013,8]]},"abstract":"ABSTRACT<\/jats:title>Objective<\/jats:title>To compare umbilical vein (UV<\/jats:styled-content>) flow with standard Doppler parameters in prediction of adverse perinatal outcome in late\u2010onset small\u2010for\u2010gestational age (SGA<\/jats:styled-content>) fetuses.<\/jats:p><\/jats:sec>Methods<\/jats:title>Umbilical, uterine and middle cerebral arteries, and UV<\/jats:styled-content> blood flow were evaluated by Doppler before delivery in a cohort of 193 term SGA<\/jats:styled-content> fetuses. The value of the Doppler parameters to predict risk of emergency delivery for non\u2010reassuring fetal status and neonatal metabolic acidosis was analyzed.<\/jats:p><\/jats:sec>Results<\/jats:title>Fifty\u2010three (27%) fetuses had non\u2010reassuring fetal status requiring emergency delivery, whereas 21 (11%) newborns developed neonatal metabolic acidosis. Multivariable analysis showed that significant contributions to prediction of emergency delivery for non\u2010reassuring fetal status and neonatal metabolic acidosis were provided by middle cerebral artery (MCA<\/jats:styled-content>) pulsatility index (PI<\/jats:styled-content>) and UV<\/jats:styled-content> blood flow normalized by fetal weight. Decision tree analysis defined three groups with increasing risk of need for emergency delivery for non\u2010reassuring fetal status: MCA\u2010PI<\/jats:styled-content> > 1.46 (risk 15.6%); MCA\u2010PI<\/jats:styled-content>\u2009\u2264\u20091.46 and UV<\/jats:styled-content> blood flow > 68 mL<\/jats:styled-content>\/min\/kg (risk 25%); and MCA\u2010PI<\/jats:styled-content>\u2009\u2264\u20091.46 and UV<\/jats:styled-content> flow\u2009\u2264\u200968 mL<\/jats:styled-content>\/min\/kg (risk 53.1%); and two groups with different risks of neonatal metabolic acidosis: UV<\/jats:styled-content> flow > 68 mL<\/jats:styled-content>\/min\/kg or UV<\/jats:styled-content> flow\u2009\u2264\u200968 mL<\/jats:styled-content>\/min\/kg and MCA\u2010PI<\/jats:styled-content> > 1.23 (risk \u2264 10%); and UV<\/jats:styled-content> flow\u2009\u2264\u200968 mL<\/jats:styled-content>\/min\/kg and MCA\u2010PI<\/jats:styled-content>\u2009\u2264 1.23 (risk 39.1%).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The evaluation of UV<\/jats:styled-content> blood flow with spectral brain Doppler allows better identification of SGA<\/jats:styled-content> fetuses with late\u2010onset intrauterine growth restriction at risk of adverse perinatal outcome. Copyright \u00a9 2013 ISUOG. 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