{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T12:19:51Z","timestamp":1784895591281,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,9,2]],"date-time":"2013-09-02T00:00:00Z","timestamp":1378080000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine the pathological basis and clinical associations of excessively thick placentae observed at second\u2010trimester ultrasound examination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a retrospective cohort of 19 singleton high\u2010risk second\u2010trimester pregnancies noted to have a placental length\u2010to\u2010maximum thickness ratio \u2264\u20092.0, maximum sonographic placental thickness was correlated with clinical outcome, maximum placental thickness after delivery and placental pathological findings. Results were compared with those of an intermediate group of 21 high\u2010risk pregnancies with normal placental dimensions and a control group of 18 low\u2010risk pregnancies also with normal placental dimensions. Increased maximum placental thickness (&gt;\u200928\u2009mm) and abnormal placental deflation following delivery (pathology\u2009\u2212\u2009sonography difference in maximum placental thickness &lt;\u2009\u22122 mm) were defined by the upper and lower quartile values, respectively, in the control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study group exhibited significantly more adverse outcomes and gross pathological placental features compared with both intermediate and control groups. Despite increased sonographic maximum placental thickness in the study group (median, 55 (range, 40\u201375) mm compared with both the intermediate group (median, 27 (range, 22\u201341) mm, <jats:italic>P<\/jats:italic> &lt;\u20090.0001) and the control group (median 26 (range, 23\u201336) mm, <jats:italic>P<\/jats:italic> &lt;\u20090.0001)), all three groups had similar maximal placental thickness following delivery (study group: median, 24 (range, 10\u201350) mm vs intermediate group: median, 27 (range, 15\u201340) mm, <jats:italic>P<\/jats:italic> = 0.82 and vs control group: median, 28.5 (range, 18\u201344), <jats:italic>P<\/jats:italic> = 0.42). Pathology\u2009\u2212\u2009sonography difference in maximum placental thickness in the study group (median, \u201330 (range, \u201342 to 0) mm) was significantly greater than that in either the intermediate (median, \u20132 (range, \u201311 to 9) mm, <jats:italic>P<\/jats:italic> &lt;\u20090.0001) or the control (median, 1.5 (range, \u201310 to 18) mm, <jats:italic>P<\/jats:italic> &lt;\u20090.0001) group and was significantly associated with abnormal development of the gas\u2010exchanging placental villi (distal villous hypoplasia) (<jats:italic>P<\/jats:italic> = 0.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Increased second\u2010trimester sonographic maximum placental thickness represents a pathological finding associated with severe adverse perinatal outcome. This observation is due to overinflation of the intervillous space by maternal blood rather than to adaptive formation of functional placental tissue. Copyright \u00a9 2013 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.12386","type":"journal-article","created":{"date-parts":[[2013,1,3]],"date-time":"2013-01-03T10:52:56Z","timestamp":1357210376000},"page":"315-321","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Placental hyperinflation and the risk of adverse perinatal outcome"],"prefix":"10.1002","volume":"42","author":[{"given":"S.","family":"Porat","sequence":"first","affiliation":[{"name":"Department of Obstetrics &amp; Gynaecology, Mount Sinai Hospital University of Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Fitzgerald","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Mount Sinai Hospital University of Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Wright","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynaecology, Mount Sinai Hospital University of Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Keating","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Mount Sinai Hospital University of Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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