{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T09:52:19Z","timestamp":1783072339153,"version":"3.54.6"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,9,2]],"date-time":"2013-09-02T00:00:00Z","timestamp":1378080000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>In fetal tachycardia, pharmacological therapy with digoxin, flecainide and sotalol has been reported to be effective. In a recent retrospective multicenter study, sotalol was considered to be less effective than the other drugs in treatment of fetal supraventricular tachycardia (<jats:styled-content style=\"fixed-case\">SVT<\/jats:styled-content>). The aim of this study was to re\u2010evaluate the efficacy and safety of maternally administered sotalol in the treatment of fetal tachycardia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective review of the records of 30 consecutive fetuses with tachycardia documented on M\u2010mode echocardiography between January 2004 and December 2010 at Wilhelmina Children's Hospital, a tertiary referral university hospital. Patients were subdivided into those diagnosed with supraventricular tachycardia and those with atrial flutter (<jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>) and presence of hydrops was noted. Other variables investigated included <jats:styled-content style=\"fixed-case\">QTc<\/jats:styled-content> interval measured on maternal electrocardiogram before and after initiation of antiarrhythmic therapy, fetal heart rhythm and heart rate pre\u2010 and postnatally, oral maternal drug therapy used, time to conversion to sinus rhythm (<jats:styled-content style=\"fixed-case\">SR<\/jats:styled-content>), percentage of fetuses converted following transplacental treatment, maternal adverse effects, presence or absence of tachycardia as noted on postnatal <jats:styled-content style=\"fixed-case\">ECG<\/jats:styled-content>, postnatal therapy or prophylaxis and neonatal outcome. Findings are discussed with reference to the literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 28 patients (18 with <jats:styled-content style=\"fixed-case\">SVT<\/jats:styled-content>, 10 with <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>) were treated with sotalol as first\u2010line therapy. Fetal hydrops was present in six patients (five with <jats:styled-content style=\"fixed-case\">SVT<\/jats:styled-content>, one with <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>). All hydropic patients converted antenatally to <jats:styled-content style=\"fixed-case\">SR<\/jats:styled-content> (67% with sotalol as a single\u2010drug therapy, 33% after addition of flecainide). Of the non\u2010hydropic patients, 91% converted to <jats:styled-content style=\"fixed-case\">SR<\/jats:styled-content> (90% with sotalol only, 10% after addition of flecainide or digoxin). In 9% (with <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>) rate control was achieved. There was no mortality. No serious drug\u2010related adverse events were observed. Postnatally, rhythm disturbances were detected in 10 patients, two of whom still had <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>. In eight, <jats:styled-content style=\"fixed-case\">SVT<\/jats:styled-content> was observed within 3 weeks postnatally, and in five of these within 72 hours.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Sotalol can be recommended as the drug of first choice for treatment of fetal <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content> and has been shown to be an effective and safe first\u2010line treatment option for <jats:styled-content style=\"fixed-case\">SVT<\/jats:styled-content>, at least in the absence of hydrops. Postnatal maintenance therapy after successful prenatal therapy is not necessarily indicated, as the risk of recurrence is low beyond 72 hours of age. Copyright \u00a9 2013 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.12390","type":"journal-article","created":{"date-parts":[[2013,1,10]],"date-time":"2013-01-10T17:44:48Z","timestamp":1357839888000},"page":"285-293","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Sotalol as first\u2010line treatment for fetal tachycardia and neonatal follow\u2010up"],"prefix":"10.1002","volume":"42","author":[{"given":"L. B.","family":"van der Heijden","sequence":"first","affiliation":[{"name":"Department of Pediatric Cardiology University Medical Centre Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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