{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:10:36Z","timestamp":1790482236006,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,6,27]],"date-time":"2013-06-27T00:00:00Z","timestamp":1372291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2013,8]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objective<\/jats:title>\n \n To evaluate the 2\u2010year neurodevelopmental outcome of full\u2010term, small\u2010for\u2010gestational\u2010age (\n SGA<\/jats:styled-content>\n ) newborns with normal placental function, according to current criteria based on umbilical artery Doppler findings.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A cohort of consecutive full\u2010term,\n SGA<\/jats:styled-content>\n newborns with normal prenatal umbilical artery Doppler was compared with a group of full\u2010term, appropriate\u2010for\u2010gestational\u2010age (\n AGA<\/jats:styled-content>\n ) infants sampled from our general neonatal population. Neurodevelopmental outcome was evaluated at 24\u2009months' corrected age using the Bayley Scales of Infant and Toddler Development, 3\n rd<\/jats:sup>\n Edition (Bayley\u2010\n III<\/jats:styled-content>\n ), which evaluates cognitive, language, motor, social\u2010emotional and adaptive competencies.\u2009The effect of the study group on each domain was adjusted with\n MANCOVA<\/jats:styled-content>\n and logistic regression for gestational age at delivery, socioeconomic status, gender, tobacco smoking and breastfeeding.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 223 infants (112\n SGA<\/jats:styled-content>\n and 111\n AGA<\/jats:styled-content>\n ) were included. The groups differed significantly with respect to socioeconomic status and gestational age at delivery. All studied neurodevelopmental domains were poorer in the\n SGA<\/jats:styled-content>\n group, reaching significance for the cognitive (92.9\n vs<\/jats:italic>\n 100.2, adjusted\n P<\/jats:italic>\n \u2009=\u20090.027), language (94.7\n vs<\/jats:italic>\n 101, adjusted\n P<\/jats:italic>\n \u2009=\u20090.025), motor (94.2\n vs<\/jats:italic>\n 100, adjusted\n P<\/jats:italic>\n \u2009=\u20090.027) and adaptive (89.2\n vs<\/jats:italic>\n 96.5, adjusted\n P<\/jats:italic>\n \u2009=\u20090.012) scores.\u2009Likewise, the\n SGA<\/jats:styled-content>\n group had a higher risk of low scores in language (odds ratio (\n OR<\/jats:styled-content>\n )\u2009=\u20092.63; adjusted\n P<\/jats:italic>\n \u2009=\u20090.045) and adaptive (\n OR<\/jats:styled-content>\n \u2009=\u20092.72; adjusted\n P<\/jats:italic>\n \u2009=\u20090.009) domains.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Compared with normal\u2010sized babies, full\u2010term\n SGA<\/jats:styled-content>\n infants, without placental insufficiency defined according to currently used criteria, have lower 2\u2010year neurodevelopmental scores. These data challenge the concept that\n SGA<\/jats:styled-content>\n fetuses with normal umbilical artery Doppler are \u2018constitutionally small\u2019 but otherwise completely normal. Copyright \u00a9 2013 ISUOG. Published by John Wiley & Sons Ltd.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/uog.12391","type":"journal-article","created":{"date-parts":[[2013,1,10]],"date-time":"2013-01-10T12:39:02Z","timestamp":1357821542000},"page":"201-206","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":132,"title":["Neurodevelopmental outcome of full\u2010term small\u2010for\u2010gestational\u2010age infants with normal placental function"],"prefix":"10.1002","volume":"42","author":[{"given":"S.","family":"Savchev","sequence":"first","affiliation":[{"name":"Perinatal Research Group Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Sanz\u2010Cortes","sequence":"additional","affiliation":[{"name":"Perinatal Research Group Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Barcelona Spain"},{"name":"Maternal\u2010Fetal Medicine Department Hospital Cl\u00ednic, University of Barcelona Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Cruz\u2010Martinez","sequence":"additional","affiliation":[{"name":"Maternal\u2010Fetal Medicine Department Hospital Cl\u00ednic, University of Barcelona Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Arranz","sequence":"additional","affiliation":[{"name":"Perinatal Research Group Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Barcelona Spain"},{"name":"Maternal\u2010Fetal Medicine Department Hospital Cl\u00ednic, University of Barcelona Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Botet","sequence":"additional","affiliation":[{"name":"Maternal\u2010Fetal Medicine Department Hospital Cl\u00ednic, University of Barcelona Barcelona, Spain"},{"name":"University of Barcelona Barcelona Spain"},{"name":"Neonatal Unit, Hospital Cl\u00ednic University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Gratacos","sequence":"additional","affiliation":[{"name":"Perinatal Research Group Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Barcelona Spain"},{"name":"Maternal\u2010Fetal Medicine Department Hospital Cl\u00ednic, University of Barcelona Barcelona, Spain"},{"name":"University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Figueras","sequence":"additional","affiliation":[{"name":"Perinatal Research Group Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Barcelona Spain"},{"name":"Maternal\u2010Fetal Medicine Department Hospital Cl\u00ednic, University of Barcelona Barcelona, Spain"},{"name":"University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,6,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61577-8"},{"key":"e_1_2_6_3_1","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1542\/peds.97.1.18","article-title":"The behavioral and emotional well\u2010being of school\u2010age children with different birth weights","volume":"97","author":"McCormick MC","year":"1996","journal-title":"Pediatrics"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.1995.tb00847.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-199602000-00011"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073807302605"},{"key":"e_1_2_6_7_1","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1542\/peds.50.1.50","article-title":"The small\u2010for\u2010date infant. II. Neurological and intellectual sequelae","volume":"50","author":"Fitzhardinge PM","year":"1972","journal-title":"Pediatrics"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.08.004"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-2343"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00441967"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.112.2.301"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-2040"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000128983.54614.7E"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.105.2.385"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(93)90156-D"},{"issue":"6","key":"e_1_2_6_16_1","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1542\/peds.98.6.1167","article-title":"Cognitive and neurologic development of the premature, small for gestational age infant through age 6: comparison by birth weight and gestational age","volume":"98","author":"McCarton CM","year":"1996","journal-title":"Pediatrics"},{"key":"e_1_2_6_17_1","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1542\/peds.69.3.296","article-title":"Abilities of children who were small\u2010for\u2010gestational\u2010age babies","volume":"69","author":"Harvey D","year":"1982","journal-title":"Pediatrics"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.108.1.111"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.11112"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2004.00273.x"},{"key":"e_1_2_6_21_1","unstructured":"Royal College of Obstetricians and Gynaecologists (RCOG).The Investigation and Management of the Small\u2010for\u2010Gestational\u2010Age Fetus. Green\u2010top Guideline No. 31 November 2002. RCOG: London UK."},{"key":"e_1_2_6_22_1","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/S1701-2163(16)31020-9","article-title":"The use of fetal Doppler in obstetrics","volume":"25","author":"Clinical Practice Guidelines SOGC","year":"2003","journal-title":"J Obstet Gynecol Can"},{"key":"e_1_2_6_23_1","first-page":"269","article-title":"opinion. Utility of antepartum umbilical artery Doppler velocimetry in intrauterine growth restriction. No. 188, October 1997 (replaces no. 116, November 1992). Committee on Obstetric Practice. American College of Obstetricians and Gynecologists","volume":"59","author":"Committee ACOG","year":"1997","journal-title":"Int J Gynaecol Obstet"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2008.01670.x"},{"issue":"474","key":"e_1_2_6_25_1","first-page":"e1","article-title":"Cerebral blood perfusion and neurobehavioral performance in full\u2010term small\u2010for\u2010gestational\u2010age fetuses","volume":"201","author":"Cruz\u2010Martinez R","year":"2009","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2007.02.016"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-3346"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.10150"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2006.12.015"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1975.tb00710.x"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpme.1990.18.3.165"},{"key":"e_1_2_6_32_1","volume-title":"Bayley Scales of Infant and Toddler Development \u2010 Third Edition: Administration Manual","author":"Bayley N.","year":"2006"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(98)00046-3"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004310000680"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1136\/fn.86.2.F108"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2002.122292"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(89)90783-7"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02441484"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7724"},{"key":"e_1_2_6_40_1","doi-asserted-by":"crossref","DOI":"10.1007\/978-0-387-29149-9","volume-title":"Clinical Assessment of Child and Adolescent Intelligence","author":"Kamphaus R.","year":"2005"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.5.625"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.2307\/1602366"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.2307\/1602367"},{"key":"e_1_2_6_44_1","doi-asserted-by":"crossref","unstructured":"SpittleAJ OrtonJ DoyleLW BoydR. Early developmental intervention programs post hospital discharge to prevent motor and cognitive impairments in preterm infants.Cochrane Database Syst Rev2007: CD005495.","DOI":"10.1002\/14651858.CD005495.pub2"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.2522\/ptj.20100205"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-0331"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2010.09.022"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpediatrics.2010.20"},{"key":"e_1_2_6_49_1","volume-title":"Bayley Scales of Infant Development\u2013Second edition","author":"Bayley N.","year":"1993"}],"container-title":["Ultrasound in Obstetrics & Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.12391","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.12391","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T01:54:04Z","timestamp":1696470844000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.12391"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,27]]},"references-count":48,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["10.1002\/uog.12391"],"URL":"https:\/\/doi.org\/10.1002\/uog.12391","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,27]]},"assertion":[{"value":"2012-12-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-06-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}