{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T05:09:43Z","timestamp":1792300183932,"version":"4.4.0"},"reference-count":86,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,4,22]],"date-time":"2013-04-22T00:00:00Z","timestamp":1366588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare early <jats:italic>vs<\/jats:italic> late administration of low\u2010dose aspirin on the risk of perinatal death and adverse perinatal outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Databases were searched for keywords related to aspirin and pregnancy. Only randomized controlled trials that evaluated the prophylactic use of low\u2010dose aspirin (50\u2013150 mg\/day) during pregnancy were included. The primary outcome combined fetal and neonatal death. Pooled relative risks (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>) with their 95% <jats:styled-content style=\"fixed-case\">CIs<\/jats:styled-content> were compared according to gestational age at initiation of low\u2010dose aspirin (\u2264\u200916 <jats:italic>vs<\/jats:italic> &gt;\u200916 weeks of gestation).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of 8377 citations, 42 studies (27\u2009222 women) were included. Inclusion criteria were risk factors for pre\u2010eclampsia, including: nulliparity, multiple pregnancy, chronic hypertension, cardiovascular or endocrine disease, prior gestational hypertension or fetal growth restriction, and\/or abnormal uterine artery Doppler. When compared with controls, low\u2010dose aspirin started at \u2264\u200916 weeks' gestation compared with low\u2010dose aspirin started at &gt;16 weeks' gestation was associated with a greater reduction of perinatal death (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>\u2009=\u20090.41 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 0.19\u20130.92) <jats:italic>vs<\/jats:italic> 0.93 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 0.73\u20131.19), <jats:italic>P<\/jats:italic>\u2009=\u20090.02), pre\u2010eclampsia (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>\u2009=\u20090.47 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 0.36\u20130.62) <jats:italic>vs<\/jats:italic> 0.78 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 0.61\u20130.99), <jats:italic>P<\/jats:italic> &lt; 0.01), severe pre\u2010eclampsia (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>\u2009=\u20090.18 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 0.08\u20130.41)\n<jats:italic>vs<\/jats:italic> 0.65 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 0.40\u20131.07), <jats:italic>P<\/jats:italic> &lt; 0.01), fetal growth restriction (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>\u2009=\u20090.46 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 0.33\u20130.64) <jats:italic>vs<\/jats:italic> 0.98 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 0.88\u20131.08), <jats:italic>P<\/jats:italic> &lt; 0.001) and preterm birth (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>\u2009=\u20090.35 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 0.22\u20130.57) <jats:italic>vs<\/jats:italic> 0.90 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 0.83\u20130.97), <jats:italic>P<\/jats:italic> &lt; 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Low\u2010dose aspirin initiated at \u2264\u200916 weeks of gestation is associated with a greater reduction of perinatal death and other adverse perinatal outcomes than when initiated at &gt;16 weeks. Copyright \u00a9 2013 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.12421","type":"journal-article","created":{"date-parts":[[2013,1,29]],"date-time":"2013-01-29T18:20:00Z","timestamp":1359483600000},"page":"491-499","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":332,"title":["Prevention of perinatal death and adverse perinatal outcome using low\u2010dose aspirin: a meta\u2010analysis"],"prefix":"10.1002","volume":"41","author":[{"given":"S.","family":"Roberge","sequence":"first","affiliation":[{"name":"Department of Social and Preventive Medicine Faculty of Medicine, Universit\u00e9 Laval  Quebec City QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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