{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T01:58:45Z","timestamp":1791424725795,"version":"4.3.3"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,6,24]],"date-time":"2013-06-24T00:00:00Z","timestamp":1372032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p><jats:italic>To investigate neonatal morbidity in fetuses with severe congenital diaphragmatic hernia (<jats:styled-content style=\"fixed-case\">CDH<\/jats:styled-content>) treated with fetoscopic endoluminal tracheal occlusion (<jats:styled-content style=\"fixed-case\">FETO<\/jats:styled-content>) and compare it with historical controls with less severe forms of <jats:styled-content style=\"fixed-case\">CDH<\/jats:styled-content> that were managed expectantly<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:italic>This was a prospective, multicenter study on neonatal outcomes and prenatal predictors in 90 <jats:styled-content style=\"fixed-case\">FETO<\/jats:styled-content> survivors (78 left\u2010sided, 12 right) and 41 controls from the antenatal <jats:styled-content style=\"fixed-case\">CDH<\/jats:styled-content> registry with either severe or moderate hypoplasia who were managed expectantly. We also investigated early neonatal morbidity indicators, including the need for patch repair, duration of mechanical ventilation and supplemental oxygen, age at full enteral feeding and incidence of pulmonary hypertension<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>Gestational age at delivery was predictive of duration of assisted ventilation (<\/jats:italic>P\u2009=\u2009<jats:italic>0.046), days on supplemental oxygen (<\/jats:italic>P\u2009=\u2009<jats:italic>0.019) and age at full enteral feeding (<\/jats:italic>P\u2009=\u2009<jats:italic>0.020). When delivery took place after 34 weeks' gestation, neonatal morbidity of <jats:styled-content style=\"fixed-case\">FETO<\/jats:styled-content> cases was comparable with that of expectantly managed cases with moderate hypoplasia<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:italic>Fetal intervention for severe <jats:styled-content style=\"fixed-case\">CDH<\/jats:styled-content> is associated with neonatal morbidity that is comparable with that of an expectantly managed group with less severe disease. Copyright \u00a9 2013 ISUOG. Published by John Wiley &amp; Sons Ltd<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.12445","type":"journal-article","created":{"date-parts":[[2013,2,26]],"date-time":"2013-02-26T21:20:44Z","timestamp":1361913644000},"page":"77-83","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":88,"title":["Predictors of neonatal morbidity in fetuses with severe isolated congenital diaphragmatic hernia undergoing fetoscopic tracheal occlusion"],"prefix":"10.1002","volume":"42","author":[{"given":"E.","family":"Don\u00e9","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Division of Woman and Child University Hospitals Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Gratacos","sequence":"additional","affiliation":[{"name":"Hospital Clinic\u2010IDIBAPS University of Barcelona and CIBER\u2010ER Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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