{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T18:34:21Z","timestamp":1774031661108,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,11,24]],"date-time":"2013-11-24T00:00:00Z","timestamp":1385251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p><jats:italic>To assess the accuracy of magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>) and transrectal ultrasound (<jats:styled-content style=\"fixed-case\">TRUS<\/jats:styled-content>) in the evaluation of tumor size and in the\u2009detection of residual tumor following neoadjuvant chemotherapy (<jats:styled-content style=\"fixed-case\">NACT<\/jats:styled-content>) in patients with cervical cancer<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:italic>This was a prospective study involving 42 women with locally advanced histologically confirmed cervical cancer referred for<jats:styled-content style=\"fixed-case\">NACT<\/jats:styled-content>. Clinical examination,<jats:styled-content style=\"fixed-case\">TRUS<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>were performed before and after<jats:styled-content style=\"fixed-case\">NACT<\/jats:styled-content>. The tumor volume was calculated using three standardized diameters (anteroposterior, laterolateral and craniocaudal) that were measured using both<jats:styled-content style=\"fixed-case\">TRUS<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>. Thereafter patients underwent surgical treatment and the same tumor measurements were taken by a pathologist using a fixed surgical specimen. Tumor volumes were calculated from tumor dimensions using the ellipsoid formula, and data obtained from both imaging methods were compared with pathological results as the gold standard<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>Twelve cases were excluded from the study owing to disease progression (these patients were referred for primary radiotherapy) or inability to perform<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>, leaving data from 30 patients for the final analysis. On average, tumor volume decreased after<jats:styled-content style=\"fixed-case\">NACT<\/jats:styled-content>by 84.6 and 87.1% as measured by<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">TRUS<\/jats:styled-content>, respectively. The agreement between measurements obtained by<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>and histology did not reach significance (intraclass correlation coefficient, 0.344 (95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, \u20130.013 to 0.610)<\/jats:italic>, P\u2009=\u2009<jats:italic>0.059), while agreement between<jats:styled-content style=\"fixed-case\">TRUS<\/jats:styled-content>and histology was statistically significant (intraclass correlation coefficient, 0.795 (95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 0.569\u20130.902)<\/jats:italic>, P\u2009&lt;\u2009<jats:italic>0.001). The accuracy of residual tumor detection (for non\u2010microscopic tumors &gt;\u20095\u2009mm<jats:sup>3<\/jats:sup>in volume) reached 77% for both<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">TRUS<\/jats:styled-content>. The sensitivity of<jats:styled-content style=\"fixed-case\">TRUS<\/jats:styled-content>was, however, lower than that of<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>(83<\/jats:italic>vs<jats:italic>96%). The positive predictive values were similar for the two methods<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:italic><jats:styled-content style=\"fixed-case\">TRUS<\/jats:styled-content>should be considered as an accurate diagnostic method in the evaluation of tumor volume after<jats:styled-content style=\"fixed-case\">NACT<\/jats:styled-content>in patients with cervical cancer and may constitute a reliable alternative imaging method to<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>. Copyright \u00a9 2013 ISUOG. Published by John Wiley &amp; Sons Ltd<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.12455","type":"journal-article","created":{"date-parts":[[2013,3,13]],"date-time":"2013-03-13T19:53:16Z","timestamp":1363204396000},"page":"705-712","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Transrectal ultrasound and magnetic resonance imaging in the evaluation of tumor size following neoadjuvant chemotherapy for locally advanced cervical cancer"],"prefix":"10.1002","volume":"42","author":[{"given":"I.","family":"Pinkavova","sequence":"first","affiliation":[{"name":"Gynecologic Oncology Centre, Department of Obstetrics and Gynecology First Faculty of Medicine and General University Hospital, Charles University Prague Czech Republic"},{"name":"Faculty of Medicine Masaryk University Brno Czech 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