{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T12:42:38Z","timestamp":1789389758632,"version":"build-2803163510"},"reference-count":9,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,6,24]],"date-time":"2013-06-24T00:00:00Z","timestamp":1372032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>High\u2010intensity focused ultrasound (<jats:styled-content style=\"fixed-case\">HIFU<\/jats:styled-content>) has excellent potential as a non\u2010invasive therapeutic tool in various fields of medicine. We present a case of twin reversed arterial perfusion sequence, in which non\u2010invasive blood flow occlusion in the acardiac fetus was successfully achieved by means of <jats:styled-content style=\"fixed-case\">HIFU<\/jats:styled-content> exposure from outside the maternal abdomen. <jats:styled-content style=\"fixed-case\">HIFU<\/jats:styled-content> was applied to blood vessels of the acardiac fetus at the point at which the umbilical cord entered the body in a series of four procedures at 3\u2010day intervals starting at 13 weeks' gestation, and in a final procedure with higher power at 17 weeks. The <jats:styled-content style=\"fixed-case\">HIFU<\/jats:styled-content> intensity was set at approximately 2300\u2009W\/cm<jats:sup>2<\/jats:sup> for the initial series of procedures and at 4600\u2009W\/cm<jats:sup>2<\/jats:sup> for the final procedure, with exposure periods of 10\u2009s. As color Doppler examination revealed absence of blood flow to the acardiac fetus after the second round of <jats:styled-content style=\"fixed-case\">HIFU<\/jats:styled-content> exposure, we concluded that complete occlusion of target vessels had been achieved. Delivery was by Cesarean section at 37 weeks' gestation. A male neonate (the pump fetus) was born weighing 1903\u2009g with Apgar scores of 8 and 9 at 1 and 5 min, respectively. At the time of writing, the baby was healthy and growing normally, with the exception of congenital pseudarthrosis. Copyright \u00a9 2013 ISUOG. Published by John Wiley &amp; Sons Ltd<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/uog.12466","type":"journal-article","created":{"date-parts":[[2013,3,26]],"date-time":"2013-03-26T12:56:30Z","timestamp":1364302590000},"page":"112-114","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["First successful case of non\u2010invasive <i>in\u2010utero<\/i> treatment of twin reversed arterial perfusion sequence by high\u2010intensity focused ultrasound"],"prefix":"10.1002","volume":"42","author":[{"given":"T.","family":"Okai","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, School of Medicine Showa University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Ichizuka","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, School of Medicine Showa University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, School of Medicine Showa University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Matsuoka","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, School of Medicine Showa University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, School of Medicine Showa University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Shimodaira","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, School of Medicine Showa University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Sekizawa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, School of Medicine Showa University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Kushima","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine Showa University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Umemura","sequence":"additional","affiliation":[{"name":"Graduate School of Biomedical Engineering Tohoku University  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,6,24]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.11114"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-5629(03)00951-7"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.4008"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2002.125242"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.11122"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.3816"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2008.00901.x"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otsr.2011.09.001"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2011.07.007"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.12466","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.12466","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T21:12:17Z","timestamp":1696367537000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.12466"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,24]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["10.1002\/uog.12466"],"URL":"https:\/\/doi.org\/10.1002\/uog.12466","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,24]]},"assertion":[{"value":"2013-03-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-06-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}