{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T01:59:22Z","timestamp":1773799162781,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,8,4]],"date-time":"2013-08-04T00:00:00Z","timestamp":1375574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Increasingly, maternal administration of 17\u2010\u03b1\u2010hydroxyprogesterone caproate (17\u2010<jats:styled-content style=\"fixed-case\">OHPC<\/jats:styled-content>) is utilized to prevent preterm birth, but the fetal safety of 17\u2010<jats:styled-content style=\"fixed-case\">OHPC<\/jats:styled-content> is still a matter of concern. This study aimed to assess whether exposure to 17\u2010<jats:styled-content style=\"fixed-case\">OHPC<\/jats:styled-content> during the second and third trimesters of pregnancy affects fetal biometry in twin gestations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study included a subset of women with a twin pregnancy who had been previously included in a randomized clinical trial comparing the effectiveness of 17\u2010<jats:styled-content style=\"fixed-case\">OHPC<\/jats:styled-content> and placebo on neonatal outcomes and preterm birth rates in multiple pregnancy. In the present study, the individual growth patterns of femur length, head circumference and abdominal circumference were compared between fetuses of women who had been randomized to receive weekly injections of either 17\u2010<jats:styled-content style=\"fixed-case\">OHPC<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u2009=\u200952) or placebo (<jats:italic>n<\/jats:italic>\u2009=\u200958) at between 16\u201320 and 36\u2009weeks' gestation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The three biometric variables assessed developed similarly in fetuses in both the group exposed to 17\u2010<jats:styled-content style=\"fixed-case\">OHPC<\/jats:styled-content> and the placebo group during the second half of pregnancy. Birth weight adjusted for parity and fetal sex was also comparable between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The use of 17\u2010<jats:styled-content style=\"fixed-case\">OHPC<\/jats:styled-content> has no adverse effects on fetal biometry and birth weight in twins. Copyright \u00a9 2013 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.12486","type":"journal-article","created":{"date-parts":[[2013,4,16]],"date-time":"2013-04-16T14:20:44Z","timestamp":1366122044000},"page":"329-334","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Does 17\u2010\u03b1\u2010hydroxyprogesterone caproate affect fetal biometry and birth weight in twin pregnancy?"],"prefix":"10.1002","volume":"42","author":[{"given":"E. J. H.","family":"Mulder","sequence":"first","affiliation":[{"name":"Department of Obstetrics University Medical Center Utrecht (UMCU) Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. M. J.","family":"Versteegh","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Leiden University Medical Center (LUMC) Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. W. M.","family":"Bloemenkamp","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Leiden University Medical Center (LUMC) Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. C.","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Academic Medical Center (AMC) Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. W. J.","family":"Mol","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Academic Medical Center (AMC) Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. J.","family":"Bekedam","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Onze Lieve Vrouwe Gasthuis Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Kwee","sequence":"additional","affiliation":[{"name":"Department of Obstetrics University Medical Center Utrecht (UMCU) Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. W.","family":"Bruinse","sequence":"additional","affiliation":[{"name":"Department of Obstetrics University Medical Center Utrecht (UMCU) Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. C. M. L.","family":"Christiaens","sequence":"additional","affiliation":[{"name":"Department of Obstetrics University Medical Center Utrecht (UMCU) Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,8,4]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"International classification of diseases and related health problems (10th revision)","author":"World Health Organization","year":"1992"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa035140"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2003.41"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3182699a15"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcibr1100071"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1316444"},{"key":"e_1_2_6_8_1","volume-title":"Preterm birth: Causes, Consequences, and Prevention","author":"Behrman RE","year":"2006"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767050601178758"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767050802556042"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31822ad6aa"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5225"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.12.003"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.9017"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60947-8"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa070641"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.9093"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000281348.51499.bc"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1311979"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(93)90296-U"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000102055"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2007.01556.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.37957.560278.EE"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.12486","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.12486","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T10:19:10Z","timestamp":1696501150000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.12486"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,4]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["10.1002\/uog.12486"],"URL":"https:\/\/doi.org\/10.1002\/uog.12486","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,4]]},"assertion":[{"value":"2013-03-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-08-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}