{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T05:29:03Z","timestamp":1785562143246,"version":"3.56.0"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,9,2]],"date-time":"2013-09-02T00:00:00Z","timestamp":1378080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Despite fetoscopic laser ablation (<jats:styled-content style=\"fixed-case\">FLA<\/jats:styled-content>) having emerged as an effective treatment for twin\u2013twin transfusion syndrome (<jats:styled-content style=\"fixed-case\">TTTS<\/jats:styled-content>), major postintervention challenges, such as iatrogenic preterm premature rupture of membranes (<jats:styled-content style=\"fixed-case\">iPPROM<\/jats:styled-content>), remain. A chorioamniotic plug (<jats:styled-content style=\"fixed-case\">CAP<\/jats:styled-content>) made of absorbable gelatin sponge has been used to seal the trocar entry site in the chorioamniotic layers to promote healing and prevent <jats:styled-content style=\"fixed-case\">iPPROM<\/jats:styled-content>, yet the results have been equivocal. Our objective was to test the hypothesis that, following FLA for TTTS, iPPROM may be prevented by placement of an absorbable gelatin CAP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cohort study was performed on prospectively collected data from 134 consecutive patients who underwent <jats:styled-content style=\"fixed-case\">FLA<\/jats:styled-content> for <jats:styled-content style=\"fixed-case\">TTTS<\/jats:styled-content>. The decision for <jats:styled-content style=\"fixed-case\">CAP<\/jats:styled-content> placement was at the discretion of the physician. Preoperative, operative and postoperative variables were collected and analyzed. The primary outcome was the incidence of <jats:styled-content style=\"fixed-case\">iPPROM<\/jats:styled-content>, and the secondary outcomes were procedure\u2010to\u2010delivery interval and gestational age at delivery. Comparative statistical analysis was performed as appropriate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A <jats:styled-content style=\"fixed-case\">CAP<\/jats:styled-content> was placed in 72 (54%) of 134 patients. Factors significantly associated with <jats:styled-content style=\"fixed-case\">CAP<\/jats:styled-content> placement were higher gravidity (<jats:italic>P<\/jats:italic> = 0.03), anterior placentation (<jats:italic>P<\/jats:italic> = 0.04), general endotracheal intubation (<jats:italic>P<\/jats:italic> = 0.02) and a cannula diameter of 12\u2010Fr (<jats:italic>P<\/jats:italic> = 0.003). There were no differences between <jats:styled-content style=\"fixed-case\">CAP<\/jats:styled-content> and no\u2010<jats:styled-content style=\"fixed-case\">CAP<\/jats:styled-content> groups in the rate of <jats:styled-content style=\"fixed-case\">iPPROM<\/jats:styled-content> (39% <jats:italic>vs<\/jats:italic> 34%, respectively; <jats:italic>P<\/jats:italic> = 0.42) or in the procedure\u2010to\u2010delivery interval (65.3 \u00b1 34.7 days <jats:italic>vs<\/jats:italic> 58.2 \u00b1 30.8 days, respectively; <jats:italic>P<\/jats:italic> = 0.21). The gestational age at delivery was later in the <jats:styled-content style=\"fixed-case\">CAP<\/jats:styled-content> group compared with the no\u2010<jats:styled-content style=\"fixed-case\">CAP<\/jats:styled-content> group (30.7 \u00b1 4.5 weeks <jats:italic>vs<\/jats:italic> 28.9 \u00b1 3.9 weeks, respectively; <jats:italic>P<\/jats:italic> = 0.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">CAP<\/jats:styled-content> did not reduce the overall risk for <jats:styled-content style=\"fixed-case\">iPPROM<\/jats:styled-content> and did not increase the procedure\u2010to\u2010delivery interval. Further research is needed to identify other methods to prevent <jats:styled-content style=\"fixed-case\">iPPROM<\/jats:styled-content> and prolong pregnancy after laser therapy. Copyright \u00a9 2013 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.12487","type":"journal-article","created":{"date-parts":[[2013,4,18]],"date-time":"2013-04-18T16:32:55Z","timestamp":1366302775000},"page":"456-460","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Absorbable gelatin plug does not prevent iatrogenic preterm premature rupture of membranes after fetoscopic laser surgery for twin\u2013twin transfusion syndrome"],"prefix":"10.1002","volume":"42","author":[{"given":"R.","family":"Papanna","sequence":"first","affiliation":[{"name":"Section of Maternal\u2010Fetal Medicine, Obstetrics, Gynecology and Reproductive Sciences Yale School of Medicine New Haven CT USA"},{"name":"Division of Maternal\u2010Fetal Medicine, Department of Obstetrics and Gynecology Baylor College of Medicine and the Texas Children's Fetal Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. K.","family":"Mann","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences The University of Texas Medical School, and The Texas Fetal Center of Children's Memorial Hermann Hospital Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. Y.","family":"Moise","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences The University of Texas Medical School, and The Texas Fetal Center of Children's Memorial Hermann Hospital Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences The University of Texas Medical School, and The Texas Fetal Center of Children's Memorial Hermann Hospital Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"K. J.","family":"Moise","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences The University of Texas Medical School, and The Texas Fetal Center of Children's Memorial Hermann Hospital Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,9,2]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032597"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7476"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2006.01.074"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2005.03.008"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(97)70104-2"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(99)70522-3"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000076715"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(99)70338-8"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(00)70503-5"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2066"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7200292"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.2898"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/6.5.479"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/107155760200900304"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2006.01.006"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000331165"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12405"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2012.02.014"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000284624.23598.7c"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2012.07.047"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.12487","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.12487","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T19:43:37Z","timestamp":1696362217000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.12487"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9,2]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["10.1002\/uog.12487"],"URL":"https:\/\/doi.org\/10.1002\/uog.12487","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,2]]},"assertion":[{"value":"2013-02-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-04-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-09-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}