{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:57:18Z","timestamp":1792177038410,"version":"4.4.0"},"reference-count":57,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,11,24]],"date-time":"2013-11-24T00:00:00Z","timestamp":1385251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p><jats:italic>To examine the association between maternal age and a wide range of adverse pregnancy outcomes after adjustment for confounding factors in obstetric history and maternal characteristics<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:italic>This was a retrospective study in women with singleton pregnancies attending the first routine hospital visit at 11\u2009+\u20090 to 13\u2009+\u20096\u2009weeks' gestation. Data on maternal characteristics, and medical and obstetric history were collected and pregnancy outcomes ascertained. Maternal age was studied, both as a continuous and as a categorical variable. Regression analysis was performed to examine the association between maternal age and adverse pregnancy outcome including pre\u2010eclampsia, gestational hypertension, gestational diabetes mellitus (<jats:styled-content style=\"fixed-case\">GDM<\/jats:styled-content>), preterm delivery, small\u2010for\u2010gestational age (<jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content>) neonate, large\u2010for\u2010gestational age (<jats:styled-content style=\"fixed-case\">LGA<\/jats:styled-content>) neonate, miscarriage, stillbirth and elective and emergency Cesarean section<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>The study population included 76\u2009158 singleton pregnancies with a live fetus at 11\u2009+\u20090 to 13\u2009+\u20096\u2009weeks. After adjusting for potential maternal and pregnancy confounding variables, advanced maternal age (defined as \u2265\u200940\u2009years) was associated with increased risk of miscarriage (odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>), 2.32 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.83\u20132.93)<\/jats:italic>; P\u2009&lt;\u2009<jats:italic>0.001), pre\u2010eclampsia (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 1.49 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.22\u20131.82)<\/jats:italic>; P\u2009&lt;\u2009<jats:italic>0.001), <jats:styled-content style=\"fixed-case\">GDM<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 1.88 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.55\u20132.29)<\/jats:italic>; P\u2009&lt;\u2009<jats:italic>0.001), <jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 1.46 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.27\u20131.69)<\/jats:italic>; P\u2009&lt;\u2009<jats:italic>0.001) and Cesarean section (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 1.95 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.77\u20132.14)<\/jats:italic>; P\u2009&lt;\u2009<jats:italic>0.001), but not with stillbirth, gestational hypertension, spontaneous preterm delivery or <jats:styled-content style=\"fixed-case\">LGA<\/jats:styled-content><\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:italic>Maternal age should be combined with other maternal characteristics and obstetric history when calculating an individualized adjusted risk for adverse pregnancy complications. Advanced maternal age is a risk factor for miscarriage, pre\u2010eclampsia, <jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">GDM<\/jats:styled-content> and Cesarean section, but not for stillbirth, gestational hypertension, spontaneous preterm delivery or <jats:styled-content style=\"fixed-case\">LGA<\/jats:styled-content>. Copyright \u00a9 2013 ISUOG. Published by John Wiley &amp; Sons Ltd<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.12494","type":"journal-article","created":{"date-parts":[[2013,4,30]],"date-time":"2013-04-30T07:28:40Z","timestamp":1367306920000},"page":"634-643","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":321,"title":["Maternal\u00a0age\u00a0and\u00a0adverse\u00a0pregnancy\u00a0outcome:\u00a0a\u00a0cohort\u00a0study"],"prefix":"10.1002","volume":"42","author":[{"given":"A.","family":"Khalil","sequence":"first","affiliation":[{"name":"Department of Fetal Medicine, Institute for Women's Health University College London Hospitals London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Syngelaki","sequence":"additional","affiliation":[{"name":"Department of Fetal Medicine, Institute for Women's Health University College London Hospitals London UK"},{"name":"Department of Fetal Medicine King's College Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Maiz","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit, Obstetrics and Gynecology Service, BioCruces Health Research Institute Hospital Universitario Cruces, University of the Basque Country (UPV\/EHU) Barakaldo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Zinevich","sequence":"additional","affiliation":[{"name":"Department of Fetal Medicine, Institute for Women's Health University College London Hospitals London UK"},{"name":"Department of Fetal Medicine King's College Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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