{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T05:38:13Z","timestamp":1791437893179,"version":"4.3.3"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,6,24]],"date-time":"2013-06-24T00:00:00Z","timestamp":1372032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p><jats:italic>To ascertain the outcome of twin reversed arterial perfusion (<jats:styled-content style=\"fixed-case\">TRAP<\/jats:styled-content>) sequence cases managed in our unit and to review systematically cases reported in the literature treated with intrafetal laser therapy<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:italic>This was a retrospective cohort study of all <jats:styled-content style=\"fixed-case\">TRAP<\/jats:styled-content> sequence cases identified from 2000 to 2012 at our center. Pregnancy management and outcomes were ascertained from maternal and neonatal records. We also performed a meta\u2010analysis of the literature on the use of intrafetal laser therapy for the treatment of <jats:styled-content style=\"fixed-case\">TRAP<\/jats:styled-content>. Adverse pregnancy outcome was defined as a composite of intrauterine death (<jats:styled-content style=\"fixed-case\">IUD<\/jats:styled-content>) and preterm birth before 37 weeks' gestation<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>Twenty\u2010three cases of <jats:styled-content style=\"fixed-case\">TRAP<\/jats:styled-content> were identified during the study period. Six were managed conservatively and 17 were treated with laser therapy. All cases managed conservatively were complicated by <jats:styled-content style=\"fixed-case\">IUD<\/jats:styled-content> at a median gestational age of 14\u2009+\u20094 (interquartile range (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>), 12\u2009+\u20094 to 16\u2009+\u20095) weeks. Among the treated cases, 14 (82%) delivered a healthy twin at a median gestational age of 37\u2009+\u20091 (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>, 34\u2009+\u20090 to 38\u2009+\u20093) weeks. Ten studies were reviewed in detail and the data were combined with those from the current study. The overall neonatal survival was 80%. Adverse pregnancy outcome was significantly lower when the treatment was performed before 16 weeks' gestation (19<\/jats:italic> vs <jats:italic>66%<\/jats:italic>, P<jats:italic>\u2009=\u20090.0025)<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:italic>The study data demonstrate a high risk of spontaneous fetal demise in early pregnancy, lack of accurate prognostic markers and improved pregnancy outcome after laser therapy in cases of <jats:styled-content style=\"fixed-case\">TRAP<\/jats:styled-content>. In these cases we recommend elective treatment with intrafetal laser therapy at between 13 and 16 weeks' gestation. Copyright \u00a9 2013 ISUOG. Published by John Wiley &amp; Sons Ltd<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.12495","type":"journal-article","created":{"date-parts":[[2013,5,2]],"date-time":"2013-05-02T23:43:23Z","timestamp":1367538203000},"page":"6-14","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":113,"title":["Intrafetal laser treatment for twin reversed arterial perfusion sequence: cohort study and meta\u2010analysis"],"prefix":"10.1002","volume":"42","author":[{"given":"G.","family":"Pagani","sequence":"first","affiliation":[{"name":"Fetal Medicine Unit, Division of Developmental Sciences St George's Hospital Medical School  London UK"},{"name":"Maternal Fetal Medicine Unit, Department of Obstetrics and Gynecology University of Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"D'Antonio","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit, Division of Developmental Sciences St George's Hospital Medical School  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Khalil","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit, Division of Developmental Sciences St George's Hospital Medical School  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Papageorghiou","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit, Division of Developmental Sciences St George's Hospital Medical School  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Bhide","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit, Division of Developmental Sciences St George's Hospital Medical School  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Thilaganathan","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit, Division of Developmental Sciences St George's Hospital Medical School  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,6,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(90)91094-S"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1269"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.04.018"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.224"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000295176"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.91.1.129"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(03)00706-3"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1797.2010.01380.x"},{"key":"e_1_2_7_10_1","unstructured":"NHS Centre for Reviews and Dissemination. Systematic reviews: CRD's guidance for undertaking reviews in health care.York (UK): University of York; 2009."},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0040296"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-3782(87)90099-5"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/del246"},{"key":"e_1_2_7_14_1","volume-title":"Users' Guides to the Medical Literature: A Manual for Evidence\u2010Based Clinical Practice","author":"Montori V","year":"2002"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(01)00377-8"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000334156"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2001.00250.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2002.01043.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.1040"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2004.23.12.1663"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2025"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.20583"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2291"},{"key":"e_1_2_7_25_1","first-page":"865","article-title":"Interstitial laser coagulation in twin reversed arterial perfusion sequence]. [in Polish","volume":"83","author":"Wegrzyn P","year":"2012","journal-title":"Ginekol Pol"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420500306"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(90)91094-S"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/15513810801893389"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2012.10.009"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.12495","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.12495","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T21:12:10Z","timestamp":1696367530000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.12495"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,24]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["10.1002\/uog.12495"],"URL":"https:\/\/doi.org\/10.1002\/uog.12495","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,24]]},"assertion":[{"value":"2013-02-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-04-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-06-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}