{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T17:29:26Z","timestamp":1793986166762,"version":"4.8.0"},"reference-count":9,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,1,2]],"date-time":"2014-01-02T00:00:00Z","timestamp":1388620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2014,3]]},"abstract":"ABSTRACT<\/jats:title>\n \n \n In order to illustrate the significance of a new anatomical finding, distortion of the interhemispheric fissure (\n DIHF<\/jats:styled-content>\n ) associated with impacted medial borders of the frontal lobes, we report a retrospective observational study of 13 fetuses in which\n DIHF<\/jats:styled-content>\n was identified on prenatal imaging. In 10 cases there were associated anatomical anomalies, including mainly midline anomalies (syntelencephaly (\n <\/jats:italic>\n n\u2009=\u2009\n 2), lobar holoprosencephaly (<\/jats:italic>\n n\u2009=\u2009\n 1), Aicardi syndrome (<\/jats:italic>\n n\u2009=\u2009\n 2)), but also schizencephaly (<\/jats:italic>\n n\u2009=\u2009\n 1), cortical dysplasia (<\/jats:italic>\n n\u2009=\u2009\n 1) and more complex cerebral malformations (<\/jats:italic>\n n\u2009=\u2009\n \n 3), including neural tube defect in two cases. Chromosomal anomaly was identified in two cases, including 6p deletion in a case without associated central nervous system anomalies and a complex mosaicism in one of the cases with syntelencephaly. In two cases, the finding was apparently isolated on both pre\u2010 and postnatal imaging, and the children were doing well at follow\u2010up, aged 4 and 5 years. The presence of\n DIHF<\/jats:styled-content>\n on prenatal imaging may help in the diagnosis of cerebral anomalies, especially those involving the midline. If\n DIHF<\/jats:styled-content>\n is apparently isolated on prenatal ultrasound, magnetic resonance imaging is recommended for careful analysis of gyration and midline, especially optic and olfactory structures. Karyotyping is also recommended. Copyright \u00a9 2013 ISUOG. Published by John Wiley & Sons Ltd\n <\/jats:italic>\n <\/jats:p>","DOI":"10.1002\/uog.12498","type":"journal-article","created":{"date-parts":[[2013,5,2]],"date-time":"2013-05-02T19:43:21Z","timestamp":1367523801000},"page":"346-352","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Distortion of the anterior part of the interhemispheric fissure: significance and implications for prenatal diagnosis"],"prefix":"10.1002","volume":"43","author":[{"given":"N.","family":"Vinurel","sequence":"first","affiliation":[{"name":"D\u00e9partement d'Imagerie P\u00e9diatrique et Foetale H\u00f4pital Femme M\u00e8re Enfant Lyon Bron France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Van Nieuwenhuyse","sequence":"additional","affiliation":[{"name":"Centre Pluridisciplinaire de Diagnostic Pr\u00e9natal H\u00f4pital Femme M\u00e8re Enfant Lyon Bron 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France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,1,2]]},"reference":[{"key":"e_1_2_3_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.3909"},{"key":"e_1_2_3_1_3_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2010.29.3.427"},{"key":"e_1_2_3_1_4_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.152.2.353"},{"key":"e_1_2_3_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.1787"},{"key":"e_1_2_3_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5353"},{"key":"e_1_2_3_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2171"},{"key":"e_1_2_3_1_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-005-0030-0"},{"key":"e_1_2_3_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.1807"},{"key":"e_1_2_3_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2628"}],"container-title":["Ultrasound in Obstetrics & 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