{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:16:19Z","timestamp":1791386179539,"version":"4.3.3"},"reference-count":10,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,11,24]],"date-time":"2013-11-24T00:00:00Z","timestamp":1385251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2013,12]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objectives<\/jats:title>\n \n \n To assess the presence and degree of indirect signs of agenesis of the corpus callosum (\n ACC<\/jats:styled-content>\n ) according to gestational age and determine the percentage of cases in which each sign is present by 24 gestational weeks\n <\/jats:italic>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n \n We analyzed retrospectively 54 cases of\n ACC<\/jats:styled-content>\n which underwent three\u2010dimensional neurosonography at our unit between January 2005 and December 2012. A single examination was available in 48 cases and six cases were followed up longitudinally, giving a total of 69 examinations. The following variables were assessed: indication for referral, karyotype, width of the atrium and presence\/absence of colpocephaly, the cavum septi pellucidi, dorsal cyst and additional central nervous system (\n CNS<\/jats:styled-content>\n ) and non\u2010\n CNS<\/jats:styled-content>\n anomalies\n <\/jats:italic>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n \n Overall, there were 31 cases of complete\n ACC<\/jats:styled-content>\n (\n cACC<\/jats:styled-content>\n , 42 examinations) and 23 cases of partial\n ACC<\/jats:styled-content>\n (\n pACC<\/jats:styled-content>\n , 27 examinations). The mean gestational age was lower in the cases referred because of anomalies other than\n ACC<\/jats:styled-content>\n than it was in those referred because of ventriculomegaly and\/or suspicion of\n ACC<\/jats:styled-content>\n (\n <\/jats:italic>\n P\u2009<\u2009\n 0.05). Atrial width showed a positive linear correlation with advancing gestational age (<\/jats:italic>\n P\u2009<\u2009\n 0.0001); it was\u2009<\u200910.0\u2009mm in 25\/34 (73.5%) examinations\u2009<\u200924 gestational weeks and in 9\/35 (25.7%) \u2265\u200924\u2009weeks (<\/jats:italic>\n P\u2009<\u2009\n 0.001). Colpocephaly was present in 20.6% (7\/34) of examinations\u2009<\u200924\u2009weeks and in 68.6% (24\/35) of those after 23\u2009weeks (<\/jats:italic>\n P\u2009<\u2009\n \n 0.05). The cavum septi pellucidi was present and visible at least in part in 17 (63%) of the 27\n pACC<\/jats:styled-content>\n examinations. In nine of the 27 (33.3%)\n pACC<\/jats:styled-content>\n examinations, there was neither ventriculomegaly nor absence of the cavum septi pellucidi. Associated anomalies were present in 25\/54 (46.3%) cases, and in 11 these included or consisted of\n CNS<\/jats:styled-content>\n abnormalities. Karyotype was abnormal in seven of the 40 (17.5%) cases in which it was available\n <\/jats:italic>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n \n In a significant proportion of cases, most of the indirect signs of\n ACC<\/jats:styled-content>\n are either absent or barely visible at the time of the midtrimester screening ultrasound examination. Therefore,\n ACC<\/jats:styled-content>\n may escape diagnosis at midtrimester screening ultrasound. In particular, a third of examinations in fetuses with\n pACC<\/jats:styled-content>\n may not show any abnormality in the transventricular screening view\u2009<\u200924\u2009weeks. The medicolegal implications of such findings are important and should be considered. Copyright \u00a9 2013 ISUOG. Published by John Wiley & Sons Ltd\n <\/jats:italic>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/uog.12506","type":"journal-article","created":{"date-parts":[[2013,5,13]],"date-time":"2013-05-13T12:16:20Z","timestamp":1368447380000},"page":"687-690","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":80,"title":["Agenesis of the fetal corpus callosum: sonographic signs change with advancing gestational age"],"prefix":"10.1002","volume":"42","author":[{"given":"D.","family":"Paladini","sequence":"first","affiliation":[{"name":"Fetal Medicine and Surgery Unit Giannina Gaslini Institute Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Pastore","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University Federico II of Naples Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Cavallaro","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University Federico II of Naples Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Massaro","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University Federico II of Naples Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Nappi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University Federico II of Naples Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,11,24]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-003-0781-6"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199803)18:3<247::AID-PD253>3.0.CO;2-J"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1993.03050318.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.199.2.8668792"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.3909"},{"key":"e_1_2_5_7_1","volume-title":"Ultrasound of Fetal Anomalies","author":"Paladini D","year":"2008"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.2774"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7489"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.11206"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.1016"}],"container-title":["Ultrasound in Obstetrics & Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.12506","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.12506","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.12506","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T00:06:20Z","timestamp":1696464380000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.12506"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,24]]},"references-count":10,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["10.1002\/uog.12506"],"URL":"https:\/\/doi.org\/10.1002\/uog.12506","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,24]]},"assertion":[{"value":"2013-03-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-05-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-11-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}