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We review\n                      <jats:styled-content style=\"fixed-case\">NIPT<\/jats:styled-content>\n                      in the context of established screening and invasive technologies, the range of cytogenetic abnormalities detectable, cost, counseling and ethical issues. Current\n                      <jats:styled-content style=\"fixed-case\">NIPT<\/jats:styled-content>\n                      approaches involve whole\u2010genome sequencing, targeted sequencing and assessment of single nucleotide polymorphism (\n                      <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>\n                      ) differences between mother and fetus. Clinical trials have demonstrated the efficacy of\n                      <jats:styled-content style=\"fixed-case\">NIPT<\/jats:styled-content>\n                      for Down and Edwards syndromes, and possibly Patau syndrome, in high\u2010risk women. Universal\n                      <jats:styled-content style=\"fixed-case\">NIPT<\/jats:styled-content>\n                      is not cost\u2010effective, but using\n                      <jats:styled-content style=\"fixed-case\">NIPT<\/jats:styled-content>\n                      contingently in women found at moderate or high risk by conventional screening is cost\u2010effective. Positive\n                      <jats:styled-content style=\"fixed-case\">NIPT<\/jats:styled-content>\n                      results must be confirmed using invasive techniques. Established screening, fetal ultrasound and invasive procedures with microarray testing allow the detection of a broad range of additional abnormalities not yet detectable by\n                      <jats:styled-content style=\"fixed-case\">NIPT<\/jats:styled-content>\n                      .\n                      <jats:styled-content style=\"fixed-case\">NIPT<\/jats:styled-content>\n                      approaches that take advantage of\n                      <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>\n                      information potentially allow the identification of parent of origin for imbalances, triploidy, uniparental disomy and consanguinity, and separate evaluation of dizygotic twins. Fetal fraction enrichment, improved sequencing and selected analysis of the most informative sequences should result in tests for additional chromosomal abnormalities. Providing adequate prenatal counseling poses a substantial challenge given the broad range of prenatal testing options now available. Copyright \u00a9 2013 ISUOG. Published by John Wiley &amp; Sons Ltd\n                    <\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1002\/uog.12513","type":"journal-article","created":{"date-parts":[[2013,5,20]],"date-time":"2013-05-20T15:15:25Z","timestamp":1369062925000},"page":"15-33","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":293,"title":["Non\u2010invasive prenatal testing for aneuploidy: current status and future prospects"],"prefix":"10.1002","volume":"42","author":[{"given":"P.","family":"Benn","sequence":"first","affiliation":[{"name":"Department of Genetics and Developmental Biology University of Connecticut Health Center Farmington CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Cuckle","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Columbia University Medical Center New York NY 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