{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T17:49:47Z","timestamp":1774028987914,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,10,27]],"date-time":"2013-10-27T00:00:00Z","timestamp":1382832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p><jats:italic>We performed a meta\u2010analysis to examine the performance of second\u2010trimester (14\u201324\u2009weeks' gestation) isolated fetal pyelectasis as a marker for trisomy 21 and to calculate its associated weighted pooled likelihood ratios<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:italic><jats:styled-content style=\"fixed-case\">PubMed<\/jats:styled-content>, Ovid <jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content> and Cochrane databases were searched using the terms \u2018pyelectasis\u2019 and \u2018pelviectasis\u2019. Studies were included if fetuses with isolated pyelectasis were reported separately from fetuses with other soft markers of aneuploidy and\/or structural anomalies and if knowledge of the fetal karyotype was unknown at the time of ultrasound examination<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>Individual study statistics were pooled as weighted positive and negative likelihood ratios with 95% <jats:styled-content style=\"fixed-case\">CIs<\/jats:styled-content>, using a random\u2010effects model. Ten observational studies were included (2148 cases of isolated pyelectasis). Isolated fetal pyelectasis was defined in seven out of 10 studies as a renal pelvis anteroposterior diameter of \u2265\u20094\u2009mm. Isolated fetal pyelectasis was associated with pooled positive and negative likelihood ratios of 2.78 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.75\u20134.43) and 0.99 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 0.98\u20131.00), respectively<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:italic>The detection of isolated fetal pyelectasis on mid\u2010trimester ultrasound is associated with an increased likelihood of trisomy 21. If the finding of isolated fetal pyelectasis is used to adjust the trisomy 21 risk from maternal serum screening tests, a positive likelihood ratio of 2.78 should be used in the calculation. Copyright \u00a9 2013 ISUOG. Published by John Wiley &amp; Sons Ltd<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.12516","type":"journal-article","created":{"date-parts":[[2013,5,27]],"date-time":"2013-05-27T17:06:42Z","timestamp":1369674402000},"page":"615-621","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Isolated fetal pyelectasis and the risk of Down syndrome: a\u00a0meta\u2010analysis"],"prefix":"10.1002","volume":"42","author":[{"given":"K. 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