{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T04:35:03Z","timestamp":1791866103557,"version":"4.3.4"},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,1,12]],"date-time":"2014-01-12T00:00:00Z","timestamp":1389484800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2014,1,12]],"date-time":"2014-01-12T00:00:00Z","timestamp":1389484800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      <jats:italic>\n                        Sonoelastography is an ultrasound\u2010imaging technique that measures tissue strain. The aim of this study was to define, in a systematic manner, specific sonoelastographic characteristics of the myometrium, fibroids and adenomyosis, to evaluate the feasibility of sonoelastography in patients with suspected gynecological pathology and to compare the results with histology and\/or magnetic resonance imaging (\n                        <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\n                        )\u2010based diagnoses\n                      <\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      <jats:italic>\n                        We performed a prospective observational cohort study between 2009 and 2011. Two\u2010hundred and eighteen women with suspected gynecological pathology underwent routine transvaginal ultrasound and additional real\u2010time sonographic elastography. Sixty\u2010nine of the 218 women underwent\n                        <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\n                        and\/or histological examination and were included in the final analysis. Acquisition of elastographic images was standardized. We analyzed the elastographic characteristics of myometrium, fibroids and adenomyosis. An independent observer, unaware of clinical, histological or\n                        <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\n                        findings, evaluated the recorded elastographic images and cineloops. These elastographic\u2010based diagnoses were compared with histology and\/or\n                        <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\n                        diagnoses\n                      <\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>\n                        With elastography, the uterus was well delineated from the surrounding bowel. The myometrium was uniform in color in 49% of the cases, with a main color of purple or dark blue, indicating stiffer tissue. Fibroids and adenomyosis had different elastographic characteristics and different color patterns. In general, fibroids were darker and adenomyosis was brighter than adjacent myometrium. The agreement between elastography\u2010based diagnosis of fibroids and adenomyosis with\n                        <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\n                        \u2010based diagnosis was excellent; with histology\u2010based diagnosis, agreement was substantial for fibroids and adenomyosis\n                      <\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      <jats:italic>\n                        Elastography is able to identify clear discriminating characteristics of the uterus, fibroids and adenomyosis, and elastography\u2010based diagnoses are in excellent agreement with those of\n                        <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\n                        . Agreement between elastography\u2010based diagnosis of adenomyosis and histology is substantial but not optimal. Copyright \u00a9 2013 ISUOG. Published by John Wiley &amp; Sons Ltd\n                      <\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/uog.12519","type":"journal-article","created":{"date-parts":[[2013,5,23]],"date-time":"2013-05-23T15:28:38Z","timestamp":1369322918000},"page":"218-226","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":91,"title":["Real\u2010time elastography for assessment of uterine disorders"],"prefix":"10.1002","volume":"43","author":[{"given":"B.","family":"Stoelinga","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology VU Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. J. K.","family":"Hehenkamp","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology VU Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. A. M.","family":"Br\u00f6lmann","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology VU Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. A. F.","family":"Huirne","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology VU Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,1,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/016173469101300201"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/56\/1\/R01"},{"key":"e_1_2_6_4_1","first-page":"45","article-title":"Value of ultrasound elastography in the diagnosis and management of prostate carcinoma","volume":"131","author":"Dudea SM","year":"2011","journal-title":"Med Ultrason"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-012-2020-x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e3181b4af1f"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cult.2009.10.009"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2011.0054"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2006.11.010"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7358"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-011-2064-z"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.11067"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2006.01.005"},{"key":"e_1_2_6_14_1","volume-title":"Statistical Methods for Rates and Proportions (2nd edn)","author":"Fleiss JL","year":"1981"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2007.26.7.899"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.12519","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.12519","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/uog.12519","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.12519","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T17:20:49Z","timestamp":1785518449000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.12519"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,12]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["10.1002\/uog.12519"],"URL":"https:\/\/doi.org\/10.1002\/uog.12519","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,12]]},"assertion":[{"value":"2013-01-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-05-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-01-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}