{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T18:02:23Z","timestamp":1768586543257,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,2,12]],"date-time":"2014-02-12T00:00:00Z","timestamp":1392163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p><jats:italic>To evaluate the usefulness of first\u2010trimester crown\u2212rump length (<jats:styled-content style=\"fixed-case\">CRL<\/jats:styled-content>) discordance in predicting adverse outcome in twin pregnancies<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:italic>This retrospective study included a large cohort retrieved from local ultrasound databases at 14 obstetric departments in Denmark, comprising all twin pregnancies with two live fetuses scanned between 11 and 14 weeks' gestation during the period 1 January 2004 to 31 December 2006. The association between <jats:styled-content style=\"fixed-case\">CRL<\/jats:styled-content> discordance\u2009\u2265\u200910 % and adverse outcome was evaluated<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>Among 1993 twin pregnancies, 1733 were dichorionic (156 (9%) discordant; 1577 (91%) concordant) and 260 were monochorionic (32 (12%) discordant; 228 (88%) concordant). In dichorionic twin pregnancies we found an association between <jats:styled-content style=\"fixed-case\">CRL<\/jats:styled-content> discordance\u2009\u2265\u200910% and preterm delivery before 34 weeks' gestation (<\/jats:italic>P\u2009=\u2009<jats:italic>0.007), birth weight discordance (<\/jats:italic>P\u2009=\u2009<jats:italic>0.001) and mean birth weight (<\/jats:italic>P\u2009=\u2009<jats:italic>0.033). In monochorionic twin pregnancies we found an association between <jats:styled-content style=\"fixed-case\">CRL<\/jats:styled-content> discordance\u2009\u2265\u200910% and birth weight discordance (<\/jats:italic>P\u2009=\u2009<jats:italic>0.02) and mean birth weight (<\/jats:italic>P\u2009=\u2009<jats:italic>0.03). To evaluate <jats:styled-content style=\"fixed-case\">CRL<\/jats:styled-content> discordance as a predictor of fetal loss and preterm delivery before 34 weeks' gestation, receiver\u2212operating characteristics curves were created for each outcome. For <jats:styled-content style=\"fixed-case\">CRL<\/jats:styled-content> discordance\u2009\u2265\u200910% as a predictor of fetal loss and preterm delivery in dichorionic twin pregnancies, sensitivity was 0.17 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 0.06\u22120.28) and 0.14 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 0.10\u22120.18), respectively, and in monochorionic twin pregnancies it was 0.10 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 0.03\u22120.22) and 0.16 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 0.06\u22120.26), respectively<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:italic><jats:styled-content style=\"fixed-case\">CRL<\/jats:styled-content> discordance in twin pregnancies is associated with, but is not a strong predictor of, adverse outcome. Copyright \u00a9 2013 ISUOG. Published by John Wiley &amp; Sons Ltd<\/jats:italic><\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.12534","type":"journal-article","created":{"date-parts":[[2013,6,10]],"date-time":"2013-06-10T17:20:46Z","timestamp":1370884846000},"page":"277-283","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Crown\u2212rump length discordance in the first trimester: a predictor of adverse outcome in twin pregnancies?"],"prefix":"10.1002","volume":"43","author":[{"given":"M. L.","family":"Johansen","sequence":"first","affiliation":[{"name":"Center for Fetal Medicine, Department of Obstetrics and Gynecology, Rigshospitalet Copenhagen University Hospital Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Oldenburg","sequence":"additional","affiliation":[{"name":"Center for Fetal Medicine, Department of Obstetrics and Gynecology, Rigshospitalet Copenhagen University Hospital Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Rosth\u00f8j","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Cohn","family":"Maxild","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Rode","sequence":"additional","affiliation":[{"name":"Center for Fetal Medicine, Department of Obstetrics and Gynecology, Rigshospitalet Copenhagen University Hospital Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Tabor","sequence":"additional","affiliation":[{"name":"Center for Fetal Medicine, Department of Obstetrics and Gynecology, Rigshospitalet Copenhagen University Hospital Copenhagen Denmark"},{"name":"Faculty of Health Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,2,12]]},"reference":[{"key":"e_1_2_5_2_1","unstructured":"SST.DK.http:\/\/www.sst.dk\/Nyhedscenter\/Nyheder\/2004\/Foedselstal_73_03.aspx. 16\u201312\u20102004. 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