{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T16:02:46Z","timestamp":1787587366606,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,10,24]],"date-time":"2013-10-24T00:00:00Z","timestamp":1382572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p><jats:italic>To review the available literature on outcome of pregnancy when an isolated single umbilical artery (<jats:styled-content style=\"fixed-case\">iSUA<\/jats:styled-content>) is diagnosed at the time of the mid\u2010trimester anomaly scan<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:italic>We searched MEDLINE (1948\u20132012), EMBASE (1980\u20132012) and the Cochrane Library (until 2012) for relevant citations reporting on outcome of pregnancy with <jats:styled-content style=\"fixed-case\">iSUA<\/jats:styled-content> seen on ultrasound. Data were extracted by two reviewers. Where appropriate, we pooled odds ratios (<jats:styled-content style=\"fixed-case\">ORs<\/jats:styled-content>) for the dichotomous outcome measures: small for gestational age (<jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content>), perinatal mortality and aneuploidy. For birth weight we determined the mean difference with 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content><\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>We identified three cohort studies and four case\u2013control studies reporting on 928 pregnancies with <jats:styled-content style=\"fixed-case\">iSUA<\/jats:styled-content>. There was significant heterogeneity between cohort and case\u2013control studies. Compared to fetuses with a three\u2010vessel cord, fetuses with an <jats:styled-content style=\"fixed-case\">iSUA<\/jats:styled-content> were more likely to be <jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.6 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 0.97\u20132.6)<\/jats:italic>; n\u2009=\u2009<jats:italic>489) or suffer perinatal mortality (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 2.0 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 0.9\u20134.2)<\/jats:italic>; n\u2009=\u2009<jats:italic>686), although for neither of the outcomes was statistical significance reached. The difference in mean birth weight was 51\u2009g (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, \u2013154.7 to 52.6\u2009g)<\/jats:italic>: n\u2009=\u2009<jats:italic>407), but again this difference was not statistically significant. We found no evidence that fetuses with <jats:styled-content style=\"fixed-case\">iSUA<\/jats:styled-content> have an increased risk for aneuploidy<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:italic>In view of the non\u2010significant association between <jats:styled-content style=\"fixed-case\">iSUA<\/jats:styled-content> and fetal growth and perinatal mortality, and in view of the heterogeneity in studies on aneuploidy, we feel that large\u2010scale, prospective cohort studies are needed to reach definitive conclusions on the appropriate work\u2010up in <jats:styled-content style=\"fixed-case\">iSUA<\/jats:styled-content> pregnancies. At present, targeted growth assessment after diagnosis of <jats:styled-content style=\"fixed-case\">iSUA<\/jats:styled-content> should not be routine practice.  Copyright \u00a9 2013 ISUOG. Published by John Wiley &amp; Sons Ltd<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.12541","type":"journal-article","created":{"date-parts":[[2013,6,14]],"date-time":"2013-06-14T11:46:12Z","timestamp":1371210372000},"page":"622-628","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["Relationship of isolated single umbilical artery to fetal growth, aneuploidy and perinatal mortality: systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"42","author":[{"given":"B. J.","family":"Voskamp","sequence":"first","affiliation":[{"name":"Department of Obstetrics University Medical Centre AMC Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Fleurke\u2010Rozema","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Prenatal Diagnosis University of Groningen, University Medical Centre UMCG Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Oude\u2010Rengerink","sequence":"additional","affiliation":[{"name":"Department of Obstetrics University Medical Centre AMC Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. J. M.","family":"Snijders","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Prenatal Diagnosis University of Groningen, University Medical Centre UMCG Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. M.","family":"Bilardo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Prenatal Diagnosis University of Groningen, University Medical Centre UMCG Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. W. J.","family":"Mol","sequence":"additional","affiliation":[{"name":"Department of Obstetrics University Medical Centre AMC Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Pajkrt","sequence":"additional","affiliation":[{"name":"Department of Obstetrics University Medical Centre AMC Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,10,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.540"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ruq.0000263848.07808.02"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(98)90320-7"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.901"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.1998.17.12.765"},{"key":"e_1_2_6_7_1","first-page":"189","article-title":"\u201cIsolated\u201d single umbilical artery: incidence, cytogenetic abnormalities, malformation and perinatal outcome","volume":"57","author":"Volpe G","year":"2005","journal-title":"Minerva Ginecol"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1061504"},{"key":"e_1_2_6_9_1","first-page":"411","article-title":"Meta analysis of observational studies in epidemiology","volume":"48","author":"Chatenoud L","year":"2000","journal-title":"Rev Epidemiol Sante Publique"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1995.06030216.x"},{"key":"e_1_2_6_11_1","first-page":"1987","article-title":"Single umbilical artery","volume":"110","author":"Pirhonen J.","year":"1994","journal-title":"Duodecim"},{"key":"e_1_2_6_12_1","first-page":"I","article-title":"Single umbilical artery. 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