{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T08:10:27Z","timestamp":1789978227362,"version":"4.0.1"},"reference-count":49,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,3,12]],"date-time":"2014-03-12T00:00:00Z","timestamp":1394582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title><jats:styled-content style=\"fixed-case\">ABSTRACT<\/jats:styled-content><\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p><jats:italic>To explore spatial variability within the cervix and the sensitivity of shear wave speed (<jats:styled-content style=\"fixed-case\">SWS<\/jats:styled-content>) to assess softness\/stiffness differences in ripened (softened)<\/jats:italic> vs <jats:italic>unripened tissue<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:italic>We obtained <jats:styled-content style=\"fixed-case\">SWS<\/jats:styled-content> estimates from hysterectomy specimens (<\/jats:italic>n\u2009=\u2009<jats:italic>22), a subset of which were ripened (<\/jats:italic>n\u2009=\u2009<jats:italic>13). Multiple measurements were made longitudinally along the cervical canal on both the anterior and posterior sides of the cervix. Statistical tests of differences in the proximal<\/jats:italic> vs <jats:italic>distal, anterior<\/jats:italic> vs <jats:italic>posterior and ripened<\/jats:italic> vs <jats:italic>unripened cervix were performed with individual two\u2010sample<\/jats:italic> t\u2010<jats:italic>tests and a linear mixed model<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>Estimates of <jats:styled-content style=\"fixed-case\">SWS<\/jats:styled-content> increase monotonically from distal to proximal longitudinally along the cervix, they vary in the anterior compared to the posterior cervix and they are significantly different in ripened<\/jats:italic> vs <jats:italic>unripened cervical tissue. Specifically, the mid position <jats:styled-content style=\"fixed-case\">SWS<\/jats:styled-content> estimates for the unripened group were 3.45\u2009\u00b1\u20090.95\u2009m\/s (anterior; mean\u2009\u00b1\u2009SD) and 3.56\u2009\u00b1\u20090.92\u2009m\/s (posterior), and 2.11\u2009\u00b1\u20090.45\u2009m\/s (anterior) and 2.68\u2009\u00b1\u20090.57\u2009m\/s (posterior) for the ripened group (<\/jats:italic>P\u2009&lt;\u2009<jats:italic>0.001)<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:italic>We propose that <jats:styled-content style=\"fixed-case\">SWS<\/jats:styled-content> estimation may be a valuable research and, ultimately, diagnostic tool for objective quantification of cervical stiffness\/softness. Copyright \u00a9 2013 ISUOG. Published by John Wiley &amp; Sons Ltd<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.12555","type":"journal-article","created":{"date-parts":[[2013,7,8]],"date-time":"2013-07-08T18:00:55Z","timestamp":1373306455000},"page":"452-458","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":78,"title":["Estimation of shear wave speed in the human uterine cervix"],"prefix":"10.1002","volume":"43","author":[{"given":"L. C.","family":"Carlson","sequence":"first","affiliation":[{"name":"Medical Physics Department University of Wisconsin Madison WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Feltovich","sequence":"additional","affiliation":[{"name":"Medical Physics Department University of Wisconsin Madison WI USA"},{"name":"Maternal Fetal Medicine Department Intermountain Healthcare Provo UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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