{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T19:39:11Z","timestamp":1789587551340,"version":"build-2803163510"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,2,12]],"date-time":"2014-02-12T00:00:00Z","timestamp":1392163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p><jats:italic>To review the success rate of expectant management in a series of interstitial pregnancies<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:italic>We identified all women with an ultrasound diagnosis of interstitial pregnancy seen within a 9\u2010year period (January 2004 to April 2013). The clinical history, ultrasound findings and biochemical results were reviewed. The outcome of all interstitial pregnancies managed conservatively was recorded. Treatment was considered as successful when the serum \u03b2\u2010human chorionic gonadotropin (\u03b2\u2010<jats:styled-content style=\"fixed-case\">hCG<\/jats:styled-content>) level declined below 20\u2009<jats:styled-content style=\"fixed-case\">IU<\/jats:styled-content>\/L without the need for further intervention<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>A total of 48 interstitial pregnancies were diagnosed during the study period. Surgery was the first\u2010line treatment in nine (18.8%) cases. Thirty\u2010eight (79.2%) women were offered non\u2010surgical management: 19 (39.6%) had methotrexate (<jats:styled-content style=\"fixed-case\">MTX<\/jats:styled-content>) and 19 (39.6%) were managed expectantly. One (2.1%) woman returned to her local hospital following diagnosis and we were unable to obtain any follow\u2010up information regarding her care. The median initial serum \u03b2\u2010<jats:styled-content style=\"fixed-case\">hCG<\/jats:styled-content> level and ectopic size were not significantly different between any of the groups according to initial treatment. The overall success rate of expectant management was 89.5%. There were no cases of ectopic rupture in this group. Length of follow\u2010up ranged from 7 to 141\u2009days with a median duration of follow\u2010up of 50.6\u2009days<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:italic>Our data show that expectant management is an option for selected women with non\u2010viable interstitial pregnancies and declining serum \u03b2\u2010<jats:styled-content style=\"fixed-case\">hCG<\/jats:styled-content> levels, irrespective of ectopic mass size and initial serum \u03b2\u2010<jats:styled-content style=\"fixed-case\">hCG<\/jats:styled-content> levels. Copyright \u00a9 2013 ISUOG. Published by John Wiley &amp; Sons Ltd<\/jats:italic><\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.12565","type":"journal-article","created":{"date-parts":[[2013,7,19]],"date-time":"2013-07-19T10:29:08Z","timestamp":1374229748000},"page":"317-321","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["How feasible is expectant management of interstitial ectopic pregnancy?"],"prefix":"10.1002","volume":"43","author":[{"given":"L. C. Y.","family":"Poon","sequence":"first","affiliation":[{"name":"Obstetrics and Gynaecology Department Imperial College Healthcare NHS Trust, St Mary's Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Emmanuel","sequence":"additional","affiliation":[{"name":"Early Pregnancy and Gynaecology Assessment Unit King's College Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. A.","family":"Ross","sequence":"additional","affiliation":[{"name":"Early Pregnancy and Gynaecology Assessment Unit King's College Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Johns","sequence":"additional","affiliation":[{"name":"Early Pregnancy and Gynaecology Assessment Unit King's College Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,2,12]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003081-199903000-00004"},{"key":"e_1_2_5_3_1","first-page":"507","volume-title":"Telinde's Operative Gynecology","author":"Damario MA","year":"2003"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(53)90167-7"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(99)00242-3"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.1961"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1999.13020131.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(95)02589-8"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2009.07.054"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2004.00442.x"},{"key":"e_1_2_5_11_1","first-page":"1044","article-title":"Sonographic evolution of cornual pregnancies treated without surgery","volume":"79","author":"Timor\u2010Tritsch IE","year":"1992","journal-title":"Obstet Gynecol"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1994.04030238.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2010.10.025"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0001-6349.2004.0133c.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.8820"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5186"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/del433"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.12565","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.12565","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T18:50:28Z","timestamp":1696531828000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.12565"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,12]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.1002\/uog.12565"],"URL":"https:\/\/doi.org\/10.1002\/uog.12565","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,12]]},"assertion":[{"value":"2013-06-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-07-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-02-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}