{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T18:36:01Z","timestamp":1785522961045,"version":"3.56.0"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,2,4]],"date-time":"2014-02-04T00:00:00Z","timestamp":1391472000000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>\n                      Joubert syndrome and related disorders (\n                      <jats:styled-content style=\"fixed-case\">JSRD<\/jats:styled-content>\n                      ) are characterized by absence or underdevelopment of the cerebellar vermis and a malformed brainstem. This family of disorders is a member of an emerging class of diseases called ciliopathies. We describe the abnormal features of the brain, particularly the fourth ventricle, in seven fetuses affected by\n                      <jats:styled-content style=\"fixed-case\">JSRD<\/jats:styled-content>\n                      . In three cases abnormality of the fourth ventricle was isolated and in four cases there were associated malformations. The molar tooth sign (\n                      <jats:styled-content style=\"fixed-case\">MTS<\/jats:styled-content>\n                      ) was always present and visible on two\u2010dimensional ultrasound and, when performed, on three\u2010dimensional ultrasound and magnetic resonance imaging. The fourth ventricle was always abnormal, in both axial and sagittal views, presenting pathognomonic deformities. It is important to identify\n                      <jats:styled-content style=\"fixed-case\">JSRD<\/jats:styled-content>\n                      , preferably prenatally or at least postnatally, due to its high risk of recurrence of about 25%. A detailed prenatal assessment of the fourth ventricle in several views may help to achieve this goal. Copyright \u00a9 2013 ISUOG. Published by John Wiley &amp; Sons Ltd\n                    <\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1002\/uog.12567","type":"journal-article","created":{"date-parts":[[2013,7,19]],"date-time":"2013-07-19T06:29:19Z","timestamp":1374215359000},"page":"227-232","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Prenatal abnormal features of the fourth ventricle in Joubert syndrome and related disorders"],"prefix":"10.1002","volume":"43","author":[{"given":"E.","family":"Quarello","sequence":"first","affiliation":[{"name":"Unit\u00e9 d'\u00c9chographies Obst\u00e9tricales, Service de Gyn\u00e9cologie Obst\u00e9trique P\u00f4le Parents Enfants, H\u00f4pital Saint\u2010Joseph Marseille France"},{"name":"Institut de M\u00e9decine de la Reproduction Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Molho","sequence":"additional","affiliation":[{"name":"Service de Radiologie Centre Hospitalier Intercommunal de Poissy\u00a0\u2013 St Germain Poissy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Garel","sequence":"additional","affiliation":[{"name":"Service de Radiologie P\u00e9diatrique H\u00f4pital Armand Trousseau Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Couture","sequence":"additional","affiliation":[{"name":"Service de Radiologie P\u00e9diatrique H\u00f4pital Arnaud de Villeneuve Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. P.","family":"Legac","sequence":"additional","affiliation":[{"name":"Centre Pluridisciplinaire de Diagnostic Ant\u00e9natal de N\u00eemes H\u00f4pital Caremeau N\u00eemes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. L.","family":"Moutard","sequence":"additional","affiliation":[{"name":"Service de Neurologie P\u00e9diatrique H\u00f4pital Armand Trousseau Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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