{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T12:08:40Z","timestamp":1784894920600,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,4,13]],"date-time":"2014-04-13T00:00:00Z","timestamp":1397347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the accuracy of transvaginal three\u2010dimensional ultrasound with volume contrast imaging (<jats:styled-content style=\"fixed-case\">VCI<\/jats:styled-content>) for preoperative assessment of depth of myometrial invasion and cervical involvement in women with endometrial cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Transvaginal volume acquisition of the uterus was performed in 60 consecutive patients with histological diagnosis of endometrial cancer who were scheduled for primary surgical treatment. Depth of myometrial invasion and presence or absence of cervical involvement were assessed using <jats:styled-content style=\"fixed-case\">VCI<\/jats:styled-content> in multiplanar display mode. Results were compared to final postoperative histopathological findings. Patients with histological high\u2010risk cell types, including Grade 3 endometrioid adenocarcinoma, clear cell carcinoma, papillary serous carcinoma and carcinosarcoma, were excluded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty patients were included in the analysis. The accuracy of <jats:styled-content style=\"fixed-case\">VCI<\/jats:styled-content> in assessing single\u2010stage myometrial invasion (superficial or deep) was 92.5%. In the prediction of deep myometrial invasion, sensitivity, specificity, <jats:styled-content style=\"fixed-case\">PPV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">NPV<\/jats:styled-content> of <jats:styled-content style=\"fixed-case\">VCI<\/jats:styled-content> were 100%, 89.7%, 78.6% and 100%, respectively. The accuracy of <jats:styled-content style=\"fixed-case\">VCI<\/jats:styled-content> in assessing cervical involvement was 90.0%. Sensitivity, specificity, <jats:styled-content style=\"fixed-case\">PPV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">NPV<\/jats:styled-content> of <jats:styled-content style=\"fixed-case\">VCI<\/jats:styled-content> in predicting the presence of cervical involvement were 100%, 86.2%, 73.3% and 100%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Transvaginal <jats:styled-content style=\"fixed-case\">VCI<\/jats:styled-content> is an uncomplicated method that is able to predict with reasonable accuracy the depth of myometrial invasion and cervical involvement in women with endometrial cancer. Copyright \u00a9 2013 ISUOG. 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