{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T06:54:49Z","timestamp":1785308089600,"version":"3.55.0"},"reference-count":10,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,8,4]],"date-time":"2014-08-04T00:00:00Z","timestamp":1407110400000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet & Gyne"],"published-print":{"date-parts":[[2014,8]]},"abstract":"ABSTRACT<\/jats:title>Objective<\/jats:title>To assess the accuracy of expert neurosonography (two\u2010 and three\u2010dimensional NSG<\/jats:styled-content>) in the characterization of major fetal central nervous system (CNS<\/jats:styled-content>) anomalies seen at a tertiary referral center and to report the differential clinical usefulness of magnetic resonance imaging (MRI<\/jats:styled-content>) used as a second\u2010line diagnostic procedure in the same cohort.<\/jats:p><\/jats:sec>Methods<\/jats:title>This was a retrospective analysis of all 773 fetuses with confirmed CNS<\/jats:styled-content> abnormalities referred to our center between 2005 and 2012. The following variables were analyzed: gestational age at NSG<\/jats:styled-content> and MRI<\/jats:styled-content>, NSG<\/jats:styled-content> and MRI<\/jats:styled-content> diagnoses, indication for MRI<\/jats:styled-content> (confirmation of NSG<\/jats:styled-content> findings; diagnostic doubt; search for possible additional brain anomalies), association with other malformations, diagnostic accuracy of NSG<\/jats:styled-content> vs<\/jats:italic> MRI<\/jats:styled-content> (no additional clinical value for either MRI<\/jats:styled-content> or NSG<\/jats:styled-content>; additional information with clinical\/prognostic significance on MRI<\/jats:styled-content> relative to NSG<\/jats:styled-content>; additional information with clinical\/prognostic significance on NSG<\/jats:styled-content> relative to MRI<\/jats:styled-content>, NSG<\/jats:styled-content> and MRI<\/jats:styled-content> concordant but incorrect) and final diagnosis, which was made at autopsy or postnatal MRI<\/jats:styled-content>\/surgery.<\/jats:p><\/jats:sec>Results<\/jats:title>CNS<\/jats:styled-content> malformations were associated with other anomalies in 372\/773 (48.1%) cases and were isolated in the remaining 401 (51.9%) cases. NSG<\/jats:styled-content> alone was able to establish the diagnosis in 647\/773 (83.7%) cases. MRI<\/jats:styled-content> was performed in 126 (16.3%) cases. The indication for MRI<\/jats:styled-content> was: confirmation of NSG<\/jats:styled-content> diagnosis in 59 (46.8%) cases; diagnostic query (in the case of inconclusive or uncertain finding on NSG<\/jats:styled-content>) in 20 (15.9%) cases; search for possible additional brain anomalies in 47 (37.3%) cases. NSG<\/jats:styled-content> and MRI<\/jats:styled-content> were concordant and correct in 109\/126 (86.5%) cases. Clinically relevant findings were evident on MRI<\/jats:styled-content> alone in 10\/126 (7.9%) cases (1.3% of the whole population) and on NSG<\/jats:styled-content> alone in 6\/126 (4.8%) cases; in all six of these cases, MRI<\/jats:styled-content> had been performed at\u2009<\u200924 weeks of gestation. In one case, both NSG<\/jats:styled-content> and MRI<\/jats:styled-content> diagnoses were incorrect. The main type of malformation in which MRI<\/jats:styled-content> played an important diagnostic role was space\u2010occupying lesions, MRI<\/jats:styled-content> identifying clinically relevant findings in 42.9% (3\/7) of these cases.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>(1) In a tertiary referral center with good NSG<\/jats:styled-content> expertise in the assessment of fetal CNS<\/jats:styled-content> malformations, MRI<\/jats:styled-content> is likely to be of help in a limited proportion of cases; (2) MRI is more useful after 24 weeks of gestation; (3) the lesions whose diagnosis is most likely to benefit from MRI<\/jats:styled-content> are gross space\u2010occupying lesions. Copyright \u00a9 2013 ISUOG. Published by John Wiley & Sons Ltd<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.13243","type":"journal-article","created":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T22:07:41Z","timestamp":1383343661000},"page":"188-196","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Accuracy of neurosonography and MRI<\/scp> in clinical management of fetuses referred with central nervous system abnormalities"],"prefix":"10.1002","volume":"44","author":[{"given":"D.","family":"Paladini","sequence":"first","affiliation":[{"name":"Fetal Medicine and Cardiology Unit, Department of Gynecology and Obstetrics University Federico II of Naples Naples Italy"},{"name":"Fetal Medicine and Surgery Unit Giannina Gaslini Institute Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Quarantelli","sequence":"additional","affiliation":[{"name":"Biostructure and Bioimaging Institute National Research Council Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Sglavo","sequence":"additional","affiliation":[{"name":"Fetal Medicine and Cardiology Unit, Department of Gynecology and Obstetrics University Federico II of Naples Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Pastore","sequence":"additional","affiliation":[{"name":"Fetal Medicine and Cardiology Unit, Department of Gynecology and Obstetrics University Federico II of Naples Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Cavallaro","sequence":"additional","affiliation":[{"name":"Fetal Medicine and Cardiology Unit, Department of Gynecology and Obstetrics University Federico II of Naples Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. R.","family":"D'Armiento","sequence":"additional","affiliation":[{"name":"Department of Pathology University Federico II of Naples Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Salvatore","sequence":"additional","affiliation":[{"name":"Biostructure and Bioimaging Institute National Research Council Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Nappi","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics University Federico II of Naples Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,8,4]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"1688","article-title":"Fast MR imaging of fetal CNS anomalies in utero","volume":"21","author":"Simon EM","year":"2000","journal-title":"Am J Neuroradiol"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.3171\/2010.7.PEDS09511"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-008-0745-y"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.174.6.1741599"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/23696508"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.3909"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2004.00149.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2291020770"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.1016"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2002.00825.x"}],"container-title":["Ultrasound in Obstetrics & Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.13243","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.13243","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T15:12:14Z","timestamp":1696518734000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.13243"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.1002\/uog.13243"],"URL":"https:\/\/doi.org\/10.1002\/uog.13243","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8]]},"assertion":[{"value":"2013-07-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-10-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-08-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}