{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T01:58:41Z","timestamp":1791424721275,"version":"4.3.3"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,5,5]],"date-time":"2014-05-05T00:00:00Z","timestamp":1399248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p><jats:italic>To compare test characteristics of ultrasound\u2010 and magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>)\u2010derived parameters in predicting newborn survival in cases of isolated left\u2010sided congenital diaphragmatic hernia (<jats:styled-content style=\"fixed-case\">CDH<\/jats:styled-content>)<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:italic>This was a retrospective study involving 85 fetuses with an isolated left <jats:styled-content style=\"fixed-case\">CDH<\/jats:styled-content>. All had detailed prenatal evaluation, prenatal care, delivery and postnatal care at a single institution. Ultrasound images were reviewed to allow calculation of the lung\u2010to\u2010head ratio (<jats:styled-content style=\"fixed-case\">LHR<\/jats:styled-content>) and the observed\/expected <jats:styled-content style=\"fixed-case\">LHR<\/jats:styled-content> (O\/E-<jats:styled-content style=\"fixed-case\">LHR<\/jats:styled-content>), and <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> images were reviewed to determine the observed\/expected total lung volume (O\/E-<jats:styled-content style=\"fixed-case\">TLV<\/jats:styled-content>) and the percent herniated liver (%<jats:styled-content style=\"fixed-case\">HL<\/jats:styled-content>). Univariable logistic regression was used to evaluate each parameter for its ability to predict survival. Receiver\u2013operating characteristics (<jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content>) curves were constructed and test characteristics were determined for each parameter as a predictor of survival<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>The overall survival for all fetuses included was 65%. Pseudo<\/jats:italic>\u2010<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup> <jats:italic>values for all parameters were similar and were statistically significant as predictors of survival, with %HL having the highest pseudo<\/jats:italic>\u2010<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>, <jats:italic>of 0.28. ROC curve analysis showed ultrasound\u2010determined parameters (LHR and O\/E-LHR) to have a similar area under the curve (AUC), of 0.70, whilst MRI parameters (O\/E-TLV and %HL) had AUC values of 0.82 and 0.84, respectively. At ROC\u2010curve\u2010determined cut\u2010off values, MRI parameters had better test characteristics than did ultrasound parameters. At a standardized 5% false\u2010positive rate, %HL performed best, with a sensitivity of 0.54 and a specificity of 0.95. At clinically employed cut\u2010off values, sensitivity was similar for all parameters but MRI parameters provided the best combination of sensitivity and specificity, as evidenced by better likelihood ratios<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:italic>A variety of measures have been proposed as antenatal predictors of survival in CDH. Ultrasound parameters function at a similar level, whereas MRI\u2010determined parameters appear to offer better predictive value. Copyright \u00a9 2013 ISUOG. Published by John Wiley &amp; Sons Ltd<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.13271","type":"journal-article","created":{"date-parts":[[2013,12,4]],"date-time":"2013-12-04T18:52:34Z","timestamp":1386183154000},"page":"670-674","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":117,"title":["Comparison of ultrasound and magnetic resonance imaging parameters in predicting survival in isolated left\u2010sided congenital diaphragmatic hernia"],"prefix":"10.1002","volume":"43","author":[{"given":"M.","family":"Bebbington","sequence":"first","affiliation":[{"name":"Center for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia University of Pennsylvania  Philadelphia PA USA"},{"name":"The Texas Fetal Center, University of Texas Health Science Center at Houston Children's Memorial Hermann Hospital  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Victoria","sequence":"additional","affiliation":[{"name":"Center for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia University of Pennsylvania  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Danzer","sequence":"additional","affiliation":[{"name":"Center for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia University of Pennsylvania  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Moldenhauer","sequence":"additional","affiliation":[{"name":"Center for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia University of Pennsylvania  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Khalek","sequence":"additional","affiliation":[{"name":"Center for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia University of Pennsylvania  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Center for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia University of Pennsylvania  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Hedrick","sequence":"additional","affiliation":[{"name":"Center for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia University of Pennsylvania  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. S.","family":"Adzick","sequence":"additional","affiliation":[{"name":"Center for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia University of Pennsylvania  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,5,5]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-2845"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.3863"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.31.4.450"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-008-0904-x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.07.001"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(96)90338-3"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.2651"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.4052"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.6141"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.3890"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.219.1.r01ap18236"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2393050583"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.143.1.7063747"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.6234"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2013.03.033"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2011.02.060"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2011.11.020"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.13271","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.13271","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T22:31:00Z","timestamp":1696458660000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.13271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,5]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["10.1002\/uog.13271"],"URL":"https:\/\/doi.org\/10.1002\/uog.13271","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,5]]},"assertion":[{"value":"2013-09-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-11-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-05-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}