{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:56:10Z","timestamp":1792292170268,"version":"4.4.0"},"reference-count":45,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,4,4]],"date-time":"2014-04-04T00:00:00Z","timestamp":1396569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine the accuracy with which uterine artery Doppler in the first trimester of pregnancy predicts pre\u2010eclampsia and fetal growth restriction, particularly early\u2010onset disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched <jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content> (1951\u20132012), EMBASE (1980\u20132012) and the Cochrane Library (2012) for relevant citations without language restrictions. Two reviewers independently selected studies that evaluated the accuracy of first\u2010trimester uterine artery Doppler to predict adverse pregnancy outcome and performed data extraction to construct 2\u2009\u00d7\u20092 tables. We synthesized sensitivity and specificity for various Doppler indices using a bivariate random\u2010effects model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From 1866 citations, we identified 18 studies (55\u2009974 women). The sensitivity and specificity of abnormal uterine artery flow velocity waveform (<jats:styled-content style=\"fixed-case\">FVW<\/jats:styled-content>) in the prediction of early\u2010onset pre\u2010eclampsia were 47.8% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 39.0\u201356.8) and 92.1% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 88.6\u201394.6), and in the prediction of early\u2010onset fetal growth restriction were 39.2% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 26.3\u201353.8) and 93.1% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 90.6\u201395.0), respectively. The sensitivities for predicting any pre\u2010eclampsia and fetal growth restriction were 26.4% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 22.5\u201330.8) and 15.4% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 12.4\u201318.9), respectively, and the specificities were 93.4% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 90.4\u201395.5%) and 93.3% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 90.9\u201395.1), respectively. The number needed to treat (<jats:styled-content style=\"fixed-case\">NNT<\/jats:styled-content>) with aspirin to prevent one case of early\u2010onset pre\u2010eclampsia fell from 1000 to 173 and from 2500 to 421 for background risks varying between 1% and 0.4%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>First\u2010trimester uterine artery Doppler is a useful tool for predicting early\u2010onset pre\u2010eclampsia, as well as other adverse pregnancy outcomes. Based on the NNT, abnormal uterine artery Doppler in low\u2010risk women achieves a sufficiently high performance to justify aspirin prophylaxis in those who test positive. Copyright \u00a9 2013 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.13275","type":"journal-article","created":{"date-parts":[[2013,12,12]],"date-time":"2013-12-12T20:26:14Z","timestamp":1386879974000},"page":"500-507","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":238,"title":["First\u2010trimester uterine artery Doppler and adverse pregnancy outcome: a meta\u2010analysis involving 55\u2009974 women"],"prefix":"10.1002","volume":"43","author":[{"given":"L.","family":"Velauthar","sequence":"first","affiliation":[{"name":"Women's Health Research Unit, Blizard Institute, Barts and the London School of Medicine and Dentistry Queen Mary University of London  London UK"},{"name":"Women's Health Unit Barts Health NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. N.","family":"Plana","sequence":"additional","affiliation":[{"name":"Clinical Biostatistics Unit Hospital Ramon y Cajal (IRYCIS) and CIBER Epidemiolog\u00eday Salud P\u00fablica (CIBERESP)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Kalidindi","sequence":"additional","affiliation":[{"name":"Women's Health Unit Barts Health NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Zamora","sequence":"additional","affiliation":[{"name":"Clinical Biostatistics Unit Hospital Ramon y Cajal (IRYCIS) and CIBER Epidemiolog\u00eday Salud P\u00fablica (CIBERESP)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Thilaganathan","sequence":"additional","affiliation":[{"name":"The Fetal Medicine Unit, Academic Department of Obstetrics and Gynaecology St George's Hospital Medical School  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. E.","family":"Illanes","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit, Department of Obstetrics and Gynaecology Universidad de los Andes  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. S.","family":"Khan","sequence":"additional","affiliation":[{"name":"Women's Health Research Unit, Blizard Institute, Barts and the London School of Medicine and Dentistry Queen Mary University of London  London UK"},{"name":"Women's Health Unit Barts Health NHS Trust  London UK"},{"name":"Multidisciplinary Evidence Synthesis Hub (MESH), Barts and the London School of Medicine and Dentistry Queen Mary University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Aquilina","sequence":"additional","affiliation":[{"name":"Women's Health Unit Barts Health NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Thangaratinam","sequence":"additional","affiliation":[{"name":"Women's Health Research Unit, Blizard Institute, Barts and the London School of Medicine and Dentistry Queen Mary University of London  London UK"},{"name":"Women's Health Unit Barts Health NHS Trust  London UK"},{"name":"Multidisciplinary Evidence Synthesis Hub (MESH), Barts and the London School of Medicine and Dentistry Queen Mary University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,4,4]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijoa.2011.04.004"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60279-6"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5184"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2009.02.009"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003106"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa073059"},{"key":"e_1_2_5_8_1","first-page":"CG107","article-title":"Hypertension in Pregnancy: The Management of Hypertensive Disorders During Pregnancy","author":"National Institute for Health and Clinical Excellence","year":"2010","journal-title":"National Institute for Health and Clinical Excellence"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b3129"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.070430"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181e9322a"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.323.7305.157"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2004.10.012"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-3-25"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2005.02.022"},{"key":"e_1_2_5_16_1","volume-title":"Stata module for meta\u2010analysis of diagnostic accuracy","author":"Harbord RMM","year":"2008"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60712-0"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.06.014"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000077971"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2008.09.004"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.06.054"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767050802053073"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.1976"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.2814"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2660"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.02.109"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.3881"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh037"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2007.08.015"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0960-7692.2001.00596.x"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5400"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.6368"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.3855"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0960-7692.2001.00594.x"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016340601155056"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0001-6349.2005.00889.x"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61351-7"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767050902994754"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199809033391004"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38380.674340.E0"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1159\/000336662"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.8848"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.3310\/hta12060"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2002.00223.x"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.6124"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-9-22"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.13275","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.13275","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T01:11:46Z","timestamp":1696468306000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.13275"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,4]]},"references-count":45,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["10.1002\/uog.13275"],"URL":"https:\/\/doi.org\/10.1002\/uog.13275","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,4]]},"assertion":[{"value":"2013-11-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-04-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}