{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T20:31:15Z","timestamp":1792873875788,"version":"4.5.0"},"reference-count":71,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,4,2]],"date-time":"2014-04-02T00:00:00Z","timestamp":1396396800000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2014,4]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objective<\/jats:title>\n \n \n To determine, by evaluation of histological slides, images and descriptions of early (second\u2010trimester) placenta accreta (\n EPA<\/jats:styled-content>\n ) and placental implantation in cases of Cesarean scar pregnancy (\n CSP<\/jats:styled-content>\n ), whether these are pathologically indistinguishable and whether they both represent different stages in the disease continuum leading to morbidly adherent placenta in the third trimester\n <\/jats:italic>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n \n The database of a previously published review of\n CSP<\/jats:styled-content>\n and\n EPA<\/jats:styled-content>\n was used to identify articles with histopathological descriptions and electronic images for pathological review. When possible, microscopic slides and\/or paraffin blocks were obtained from the original researchers. We also included from our own institutions cases of\n CSP<\/jats:styled-content>\n and\n EPA<\/jats:styled-content>\n for which pathology specimens were available. Two pathologists examined all the material independently and, blinded to each other's findings, provided a pathological diagnosis based on microscopic appearance. Interobserver agreement in diagnosis was determined\n <\/jats:italic>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n \n Forty articles were identified, which included 31 cases of\n CSP<\/jats:styled-content>\n and 13 cases of\n EPA<\/jats:styled-content>\n containing histopathological descriptions and\/or images of the pathology. We additionally included six cases of\n CSP<\/jats:styled-content>\n and eight cases of\n EPA<\/jats:styled-content>\n from our own institutions, giving a total of 58 cases available for histological evaluation (37\n CSP<\/jats:styled-content>\n and 21\n EPA<\/jats:styled-content>\n ) containing clear definitions of morbidly adherent placenta. In the 29 cases for which images\/slides were available for histopathological evaluation, both pathologists attested to the various degrees of myometrial and\/or scar tissue invasion by placental villi with scant or no intervening decidua, consistent with the classic definition of morbidly adherent placenta. Based on the reviewed material, cases with a diagnosis of\n EPA<\/jats:styled-content>\n and those with a diagnosis of\n CSP<\/jats:styled-content>\n showed identical histopathological features. Interobserver correlation was high (kappa\u2009=\u20090.93)\n <\/jats:italic>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n \n EPA<\/jats:styled-content>\n and placental implantation in\n CSP<\/jats:styled-content>\n are histopathologically indistinguishable and may represent different stages in the disease continuum leading to morbidly adherent placenta in the third trimester. Copyright \u00a9 2013 ISUOG. Published by John Wiley & Sons Ltd\n <\/jats:italic>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/uog.13282","type":"journal-article","created":{"date-parts":[[2013,12,19]],"date-time":"2013-12-19T13:18:20Z","timestamp":1387459100000},"page":"383-395","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":220,"title":["Cesarean scar pregnancy and early placenta accreta share common histology"],"prefix":"10.1002","volume":"43","author":[{"given":"I. E.","family":"Timor\u2010Tritsch","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Maternal\u2010Fetal Medicine New York University SOM New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Monteagudo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Maternal\u2010Fetal Medicine New York University SOM New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Cali","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Arnas Civico Hospital Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M.","family":"Palacios\u2010Jaraquemada","sequence":"additional","affiliation":[{"name":"Centre for Medical Education and Clinical Research (CEMIC) University Hospital Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Maymon","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Assaf Harofeh Medical Center, Zrifin and Sackler School of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. A.","family":"Arslan","sequence":"additional","affiliation":[{"name":"Departments of Population Health, Obstetrics and Gynecology and Environmental Medicine New York University SOM New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Patil","sequence":"additional","affiliation":[{"name":"Department of Pathology Mount Sinai Medical Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Popiolek","sequence":"additional","affiliation":[{"name":"Department of Pathology New York University SOM New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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