{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:41:17Z","timestamp":1790685677797,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,6,3]],"date-time":"2014-06-03T00:00:00Z","timestamp":1401753600000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p><jats:italic>To assess whether thicknesses of the intima and media in the common carotid artery (CCA) and the intima\/media ratio (I\/M) indicate an increased cardiovascular risk in non\u2010pregnant women with a history of previous severe pre\u2010eclampsia<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:italic>Thicknesses of the <jats:styled-content style=\"fixed-case\">CCA<\/jats:styled-content> intima and media layers were measured using non\u2010invasive high\u2010frequency (22\u2009<jats:styled-content style=\"fixed-case\">MHz<\/jats:styled-content>) ultrasound  in 42 women with a history of severe pre\u2010eclampsia and 44 women with previous normal pregnancy<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>Women with a history of severe pre\u2010eclampsia had a thicker <jats:styled-content style=\"fixed-case\">CCA<\/jats:styled-content> intima and a higher I\/M than had women with previous normal pregnancy, also after adjustment for mean arterial pressure, body mass index and <jats:styled-content style=\"fixed-case\">CCA<\/jats:styled-content> intima\u2013media thickness (<jats:styled-content style=\"fixed-case\">IMT<\/jats:styled-content>) (all<\/jats:italic> <jats:italic>P<\/jats:italic>\u2009&lt;\u2009<jats:italic>0.0001). <jats:styled-content style=\"fixed-case\">CCA\u2010IMT<\/jats:styled-content> did not differ significantly between groups. In receiver\u2013operating characteristics curve analysis, intima thickness and I\/M clearly discriminated between women with and those without previous pre\u2010eclampsia (area under the receiver\u2013operating characteristics curve (AUC), 0.98 and 0.93), whereas <jats:styled-content style=\"fixed-case\">CCA\u2010IMT<\/jats:styled-content> did not (AUC, 0.52)<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:italic>CCA individual intima and media thicknesses as well as I\/M, but not CCA\u2010IMT, reflect the known increased long-term cardiovascular risk of pre\u2010eclampsia. Estimation of individual CCA layers using high\u2010frequency ultrasound appears preferable to measuring CCA\u2010IMT for investigating arterial effects and the increased cardiovascular risk in women with a history of severe pre\u2010eclampsia. Copyright \u00a9 2013 ISUOG. Published by John Wiley &amp; Sons Ltd<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.13289","type":"journal-article","created":{"date-parts":[[2013,12,21]],"date-time":"2013-12-21T00:51:17Z","timestamp":1387587077000},"page":"675-680","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Thicknesses of individual layers of artery wall indicate increased cardiovascular risk in severe pre\u2010eclampsia"],"prefix":"10.1002","volume":"43","author":[{"given":"T.","family":"Akhter","sequence":"first","affiliation":[{"name":"Department of Women's and Children's Health, Section for Obstetrics and Gynecology Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Larsson","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health, Section for Obstetrics and Gynecology Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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