{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T18:39:16Z","timestamp":1788460756735,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,8,4]],"date-time":"2014-08-04T00:00:00Z","timestamp":1407110400000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate trends in prenatal diagnosis and termination of pregnancy rates in cases of fetal cleft lip with or without cleft palate (<jats:styled-content style=\"fixed-case\">CL<\/jats:styled-content>\u00b1P), before and after the introduction in The Netherlands of the 20\u2010week anomaly scan in 2007, and to assess the accuracy of this scan for the diagnosis of facial clefts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective cohort study of consecutive cases of <jats:styled-content style=\"fixed-case\">CL<\/jats:styled-content>\u00b1P diagnosed in 2001\u20132010 in the referral region of the Academic Medical Centre. Cases diagnosed prenatally were identified from the hospital's database. These data, grouped according to the periods before and after the introduction of the routine 20\u2010week anomaly scan, were compared with data of all cases managed by the multidisciplinary cleft team, which services the same region, to identify cases of <jats:styled-content style=\"fixed-case\">CL<\/jats:styled-content>\u00b1P that were not seen prenatally.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 123 cases of <jats:styled-content style=\"fixed-case\">CL<\/jats:styled-content>\u00b1P diagnosed prenatally, of which 76% (93\/123) were diagnosed before 24 weeks. In one case, the <jats:styled-content style=\"fixed-case\">CL<\/jats:styled-content>\u00b1P was not confirmed after birth. There were 46 cases with associated structural anomalies and 76 isolated cases. The median gestational age at diagnosis decreased by 2 weeks after 2007 (<jats:italic>P<\/jats:italic>\u2009=\u20090.02). The proportion of isolated clefts detected prenatally increased significantly after 2007 (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001), whereas the proportion of associated clefts remained stable over the years (<jats:italic>P<\/jats:italic>\u2009=\u20090.426). The overall detection rate of <jats:styled-content style=\"fixed-case\">CL<\/jats:styled-content>\u00b1P increased from 43% before 2007 to 86% after 2007 (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001), without an increase in terminations of pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Introduction of the routine fetal anomaly scan has decreased the gestational age at diagnosis of <jats:styled-content style=\"fixed-case\">CL<\/jats:styled-content>\u00b1P and has increased the proportion diagnosed prenatally, without a significant change in the number of terminations of pregnancy. Copyright \u00a9 2013 ISUOG. Published by John Wiley &amp; Sons Ltd<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.13291","type":"journal-article","created":{"date-parts":[[2013,12,21]],"date-time":"2013-12-21T00:51:23Z","timestamp":1387587083000},"page":"154-159","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Influence of the 20\u2010week anomaly scan on prenatal diagnosis and management of fetal facial clefts"],"prefix":"10.1002","volume":"44","author":[{"given":"S.","family":"Ensing","sequence":"first","affiliation":[{"name":"Academic Medical Centre Department of Obstetrics and Gynecology  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. E.","family":"Kleinrouweler","sequence":"additional","affiliation":[{"name":"Academic Medical Centre Department of Obstetrics and Gynecology  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. M.","family":"Maas","sequence":"additional","affiliation":[{"name":"Academic Medical Centre Department of Clinical Genetics  Amsterdam The Netherlands"},{"name":"Academic Medical Centre Department of Pediatrics  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. M.","family":"Bilardo","sequence":"additional","affiliation":[{"name":"University of Groningen, University Medical Centre Groningen Department of Obstetrics and Gynecology  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. M. A. M.","family":"Van der Horst","sequence":"additional","affiliation":[{"name":"Academic Medical Centre Department of Plastic Surgery  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Pajkrt","sequence":"additional","affiliation":[{"name":"Academic Medical Centre Department of Obstetrics and Gynecology  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,8,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60695-4"},{"key":"e_1_2_6_3_1","volume-title":"NVSCA (Dutch Society of Orofacial Cleft and Craniofacial Malformations) database","author":"Vermey\u2010Keers C.","year":"2009"},{"key":"e_1_2_6_4_1","unstructured":"MohangooAD BuitendijkSE. Aangeboren afwijkingen in nederland 1997\u20102007; Gebaseerd op de landelijke verloskunde en neonatologie registraties. 83\u201094. 1\u201012\u20102009. 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