{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T10:43:13Z","timestamp":1790073793372,"version":"4.0.1"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,5,8]],"date-time":"2014-05-08T00:00:00Z","timestamp":1399507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p><jats:italic>Large solid sacrococcygeal teratomas (<jats:styled-content style=\"fixed-case\">SCT<\/jats:styled-content>) can cause high\u2010output cardiac failure and fetal or neonatal death. The aim of this study was to describe the outcomes of minimally invasive antenatal procedures for the treatment of fetal <jats:styled-content style=\"fixed-case\">SCT<\/jats:styled-content><\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:italic>A case review was performed of five fetuses with a large <jats:styled-content style=\"fixed-case\">SCT<\/jats:styled-content> treated antenatally using minimally invasive techniques, and a systematic literature review on fetal therapy for solid <jats:styled-content style=\"fixed-case\">SCTs<\/jats:styled-content> was carried out<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>Five women were referred between 17\u2009+\u20095 and 26\u2009+\u20094 weeks' gestation for a large fetal <jats:styled-content style=\"fixed-case\">SCT<\/jats:styled-content> with evidence of fetal cardiac failure. Vascular flow to the tumors was interrupted by fetoscopic laser ablation (<\/jats:italic><jats:italic>n<\/jats:italic>\u2009=\u2009<jats:italic>1), radiofrequency ablation (<jats:styled-content style=\"fixed-case\">RFA<\/jats:styled-content><\/jats:italic>; <jats:italic>n<\/jats:italic>\u2009=\u2009<jats:italic>2) or interstitial laser ablation\u2009\u2009\u00b1\u2009\u2009vascular coiling (<\/jats:italic><jats:italic>n<\/jats:italic>\u2009=\u2009<jats:italic>2). There were two intrauterine fetal deaths. The other three cases resulted in preterm labor within 10 days of surgery. One neonate died. Two survived without procedure\u2010related complications but had long\u2010term morbidity related to prematurity. The systematic literature review revealed 16 <jats:styled-content style=\"fixed-case\">SCTs<\/jats:styled-content> treated minimally invasively for (early) hydrops. Including our cases, six of 20 hydropic fetuses survived after minimally invasive therapy (30%). Survival after <jats:styled-content style=\"fixed-case\">RFA<\/jats:styled-content> or interstitial laser ablation was 45% (5\/11). Of 12 fetuses treated for <jats:styled-content style=\"fixed-case\">SCT<\/jats:styled-content> without obvious hydrops and for which perinatal survival data were available, eight (67%) survived. Mean gestational age at delivery after minimally invasive therapy was 29.7\u2009\u00b1\u20094.0 weeks. Survival after open fetal surgery in hydropic fetuses was 6\/11 (55%), with a mean gestational age at delivery of 29.8\u2009\u00b1\u20092.9 weeks<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:italic>Fetal therapy can potentially improve perinatal outcomes for hydropic fetuses with a solid <jats:styled-content style=\"fixed-case\">SCT<\/jats:styled-content>, but is often complicated by intrauterine death and preterm birth. Copyright \u00a9 2014 ISUOG. Published by John Wiley &amp; Sons Ltd<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.13315","type":"journal-article","created":{"date-parts":[[2014,1,31]],"date-time":"2014-01-31T14:13:23Z","timestamp":1391177603000},"page":"611-619","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":104,"title":["Minimally invasive therapy for fetal sacrococcygeal teratoma: case series and systematic review of the literature"],"prefix":"10.1002","volume":"43","author":[{"given":"T.","family":"Van Mieghem","sequence":"first","affiliation":[{"name":"Fetal Medicine Unit, Department of Obstetrics &amp; Gynaecology Mount Sinai Hospital  Toronto Ontario Canada"},{"name":"Fetal Medicine Unit, Department of Obstetrics &amp; Gynaecology University Hospitals Leuven  Leuven Belgium"},{"name":"University of Toronto Faculty of Medicine  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Al\u2010Ibrahim","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit, Department of Obstetrics &amp; Gynaecology Mount Sinai Hospital  Toronto Ontario Canada"},{"name":"University of Toronto Faculty of Medicine  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Deprest","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit, Department of Obstetrics &amp; Gynaecology University Hospitals Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Lewi","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit, Department of Obstetrics &amp; Gynaecology University Hospitals Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. C.","family":"Langer","sequence":"additional","affiliation":[{"name":"University of Toronto Faculty of Medicine  Toronto Ontario Canada"},{"name":"Division of Paediatric General Surgery Hospital For Sick Children  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Baud","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit, Department of Obstetrics &amp; Gynaecology Mount Sinai Hospital  Toronto Ontario Canada"},{"name":"University of Toronto Faculty of Medicine  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"O'Brien","sequence":"additional","affiliation":[{"name":"University of Toronto Faculty of Medicine  Toronto Ontario Canada"},{"name":"Department of Paediatrics Mount Sinai Hospital  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Beecroft","sequence":"additional","affiliation":[{"name":"University of Toronto Faculty of Medicine  Toronto Ontario Canada"},{"name":"Division of Interventional Radiology Mount Sinai Hospital  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Chaturvedi","sequence":"additional","affiliation":[{"name":"University of Toronto Faculty of Medicine  Toronto Ontario Canada"},{"name":"Division of Cardiology Hospital For Sick Children  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Jaeggi","sequence":"additional","affiliation":[{"name":"University of Toronto Faculty of Medicine  Toronto Ontario Canada"},{"name":"Division of Cardiology Hospital For Sick Children  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Fish","sequence":"additional","affiliation":[{"name":"University of Toronto Faculty of Medicine  Toronto Ontario Canada"},{"name":"Division of Paediatric Plastic Surgery Hospital For Sick Children  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Ryan","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit, Department of Obstetrics &amp; 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