{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T13:10:19Z","timestamp":1793797819113,"version":"4.6.1"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,3,4]],"date-time":"2014-03-04T00:00:00Z","timestamp":1393891200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p><jats:italic>To evaluate whether changes in the middle cerebral artery (<jats:styled-content style=\"fixed-case\">MCA<\/jats:styled-content>), umbilical artery (<jats:styled-content style=\"fixed-case\">UA<\/jats:styled-content>) and cerebroplacental ratio (<jats:styled-content style=\"fixed-case\">CPR<\/jats:styled-content>) Doppler indices at term might be used to identify those appropriate\u2010for\u2010gestational\u2010age (<jats:styled-content style=\"fixed-case\">AGA<\/jats:styled-content>) fetuses that are failing to reach their growth potential (<jats:styled-content style=\"fixed-case\">FRGP<\/jats:styled-content>)<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:italic>This was a retrospective cohort study of data obtained in a single tertiary referral center over a 10\u2010year period from 2002 to 2012. The <jats:styled-content style=\"fixed-case\">UA<\/jats:styled-content> pulsatility index (<jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content>), <jats:styled-content style=\"fixed-case\">MCA\u2010PI<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CPR<\/jats:styled-content> were recorded between 37+0 and 41+6 weeks within 14 days before delivery. The Doppler parameters were converted into multiples of the median (<jats:styled-content style=\"fixed-case\">MoM<\/jats:styled-content>), adjusting for gestational age, and their correlation with birth\u2010weight (<jats:styled-content style=\"fixed-case\">BW<\/jats:styled-content>) centiles was evaluated by means of regression analysis. Doppler indices were also grouped according to <jats:styled-content style=\"fixed-case\">BW<\/jats:styled-content> quartiles and compared using Kruskal\u2013Wallis and Dunn's<\/jats:italic> post\u2010hoc <jats:italic>tests<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>The study included 11\u2009576 term fetuses, with 8645 (74.7%) classified as <jats:styled-content style=\"fixed-case\">AGA<\/jats:styled-content>. Within the <jats:styled-content style=\"fixed-case\">AGA<\/jats:styled-content> group, fetuses with lower <jats:styled-content style=\"fixed-case\">BW<\/jats:styled-content> had significantly higher <jats:styled-content style=\"fixed-case\">UA\u2010PI<\/jats:styled-content>, lower <jats:styled-content style=\"fixed-case\">MCA\u2010PI<\/jats:styled-content> and lower <jats:styled-content style=\"fixed-case\">CPR MoM<\/jats:styled-content> values. Large\u2010for\u2010gestational\u2010age (<jats:styled-content style=\"fixed-case\">LGA<\/jats:styled-content>) fetuses were considered as the group least likely to be growth\u2010restricted. The <jats:styled-content style=\"fixed-case\">CPR MoM<\/jats:styled-content> &lt; 5<jats:sup>th<\/jats:sup> centile (0.6765 <jats:styled-content style=\"fixed-case\">MoM<\/jats:styled-content>) in these fetuses was used as a threshold for diagnosing <jats:styled-content style=\"fixed-case\">FRGP<\/jats:styled-content>. Using this definition, in the <jats:styled-content style=\"fixed-case\">AGA<\/jats:styled-content> pregnancies the percentage of fetuses with <jats:styled-content style=\"fixed-case\">FRGP<\/jats:styled-content> was 1% in the 75\u201390<jats:sup>th<\/jats:sup> <jats:styled-content style=\"fixed-case\">BW<\/jats:styled-content> centile group, 1.7% in the 50\u201375<jats:sup>th<\/jats:sup> centile group, 2.9% in the 25\u201350<jats:sup>th<\/jats:sup> centile group and 6.7% in the 10\u201325<jats:sup>th<\/jats:sup> centile group<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:italic><jats:styled-content style=\"fixed-case\">AGA<\/jats:styled-content> pregnancies may present with fetal cerebral and placental blood flow redistribution indicative of fetal hypoxemia. Fetal Doppler assessment may be of value in detecting <jats:styled-content style=\"fixed-case\">AGA<\/jats:styled-content> pregnancies that are subject to placental insufficiency, fetal hypoxemia and <jats:styled-content style=\"fixed-case\">FRGP<\/jats:styled-content>. Future studies are needed to evaluate the appropriate threshold for the diagnosis of <jats:styled-content style=\"fixed-case\">FRGP<\/jats:styled-content> and the diagnostic performance of this new approach for the management of growth disorders. Copyright \u00a9 2014 ISUOG. 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