{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T02:29:46Z","timestamp":1697682586182},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,11,3]],"date-time":"2014-11-03T00:00:00Z","timestamp":1414972800000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2014,11]]},"abstract":"ABSTRACT<\/jats:title>Objective<\/jats:title>The differential insertion of the atrioventricular valves is the ultrasonographic representation of the more apical attachment of the tricuspid valve to the septum with respect to the mitral valve. A linear insertion is present when both valves form a linear continuum and has been suggested as a marker for atrioventricular septal defects (AVSDs<\/jats:styled-content>). The objective of this study was to evaluate the anatomical substratum of differential and linear insertions of the atrioventricular valves in normal fetal hearts and fetal hearts with an AVSD<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>The extent and position of the fibrous skeleton and attachment of the atrioventricular valves to the septum were studied in histological sections of 17 normal hearts and four hearts with an AVSD<\/jats:styled-content> from 10\u2009+\u20090\u2009weeks' gestation to 3 days postpartum with various immunohistochemical tissue markers. In addition, spatiotemporal image correlation (STIC<\/jats:styled-content>) volumes of 10 normal hearts and STIC<\/jats:styled-content> volumes of eight hearts with an AVSD<\/jats:styled-content> at 13\u2009+\u20096 to 35\u2009+\u20095\u2009weeks' gestation were examined.<\/jats:p><\/jats:sec>Results<\/jats:title>The differential insertion of the atrioventricular valves was visible in normal hearts in the four\u2010chamber plane immediately beneath the aorta, but nearer the diaphragm a linear insertion was found. In hearts with an AVSD<\/jats:styled-content>, a linear appearance was observed in the four\u2010chamber plane immediately beneath the aorta. Towards the diaphragm, however, first a differential insertion and, more caudally, a linear insertion was found.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Both differential and linear insertions can be found in normal fetal hearts and fetal hearts with AVSD<\/jats:styled-content>, depending on the plane in which the four\u2010chamber view is visualized. Therefore, measurement of the differential insertion is likely to be useful only in experienced hands. Copyright \u00a9 2014 ISUOG. Published by John Wiley & Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.13326","type":"journal-article","created":{"date-parts":[[2014,2,11]],"date-time":"2014-02-11T19:53:52Z","timestamp":1392148432000},"page":"568-574","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Differential and linear insertion of atrioventricular valves: a useful tool?"],"prefix":"10.1002","volume":"44","author":[{"given":"B. M. E.","family":"Adriaanse","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology VU University Medical Center Amsterdam The Netherlands"},{"name":"Department of Anatomy and Embryology Leiden University Medical Center Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. M.","family":"Bartelings","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Embryology Leiden University Medical Center Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. M. G.","family":"van Vugt","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Chaoui","sequence":"additional","affiliation":[{"name":"Center for Prenatal Diagnosis and Human Genetics Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. C.","family":"Gittenberger\u2010de Groot","sequence":"additional","affiliation":[{"name":"Department of Cardiology Leiden University Medical Center Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. C.","family":"Haak","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Leiden University Medical Center Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,11,3]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"1738","article-title":"Normal offset of the tricuspid septal leaflet in Thai fetuses","volume":"90","author":"Tansathit T","year":"2007","journal-title":"J Med Assoc Thai"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2002.21.10.1099"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(84)90324-2"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.05.042"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000048037"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0242-6498(06)70667-8"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2670"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.1750"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(89)80605-5"},{"key":"e_1_2_6_11_1","volume-title":"Fetal Echocardiography: A Practical Guide","author":"Allan LD","year":"2009"},{"key":"e_1_2_6_12_1","first-page":"205","volume-title":"Fetal Cardiology: Embryology, Genetics, Physiology, Echocardiography, Evaluation, Diagnosis and Perinatal Management of Cardiac Diseases","author":"Birk E","year":"2008"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2000.00027.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7538"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5351"},{"key":"e_1_2_6_16_1","first-page":"296","article-title":"Anatomic observations on complete form of persistent common atrioventricular canal with special reference to atrioventricular valves","volume":"41","author":"Rastelli G","year":"1966","journal-title":"Mayo Clin Proc"}],"container-title":["Ultrasound in Obstetrics & Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.13326","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.13326","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T04:30:28Z","timestamp":1696480228000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.13326"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["10.1002\/uog.13326"],"URL":"https:\/\/doi.org\/10.1002\/uog.13326","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11]]},"assertion":[{"value":"2013-09-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-01-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-11-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}