{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T02:02:08Z","timestamp":1785722528094,"version":"3.56.0"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,10,15]],"date-time":"2014-10-15T00:00:00Z","timestamp":1413331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>A four\u2010dimensional (4D) fetal echocardiographic technique utilizing spatiotemporal image correlation, tomographic ultrasound imaging display (STIC\u2010TUI echo) and color Doppler has previously been shown to be effective in displaying the examination planes constituting the extended cardiac examination. The aim of this study was to evaluate the performance of this first\u2010trimester STIC\u2010TUI echo technique in identifying complex congenital heart disease (CHD) in high\u2010risk pregnancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective study of patients presenting at first\u2010trimester screening who were at high risk for CHD owing to pregestational diabetes, <jats:italic>in\u2010vitro<\/jats:italic> fertilization (IVF), increased nuchal translucency (NT) thickness, first\u2010trimester tricuspid regurgitation or reversed ductus venosus (DV) a\u2010wave, a previous child with CHD or who were on anticonvulsant medication. First\u2010trimester STIC\u2010TUI echo was performed, and the findings were correlated with second\u2010trimester echocardiography and post\u2010delivery echo findings in survivors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and sixty\u2010four fetuses from 152 patients were enrolled (77 diabetics, 38 IVF, 14 with increased NT, 23 cases of tricuspid regurgitation or reversed a\u2010wave in the DV, 22 with prior CHD and two on anticonvulsants). STIC\u2010TUI echo was abnormal in 20 (12%), showing atrioventricular canal defect (<jats:italic>n<\/jats:italic>\u2009=\u20099), hypoplastic left heart (<jats:italic>n<\/jats:italic>\u2009=\u20092), pulmonary stenosis (<jats:italic>n<\/jats:italic>\u2009=\u20092), right aortic arch (<jats:italic>n<\/jats:italic>\u2009=\u20091), interrupted aortic arch (<jats:italic>n<\/jats:italic>\u2009=\u20091), tricuspid atresia (<jats:italic>n<\/jats:italic>\u2009=\u20091), heterotaxy (<jats:italic>n<\/jats:italic>\u2009=\u20091),  persistent truncus arteriosus (<jats:italic>n<\/jats:italic>\u2009=\u20091), double outlet right ventricle and ventricular septal defect (<jats:italic>n<\/jats:italic>\u2009=\u20091) and double inlet ventricle with transposition of the great arteries (<jats:italic>n<\/jats:italic>\u2009=\u20091). 85% of these anomalies were evident in the four\u2010chamber view plane of the TUI display, and the remainder were diagnosed in the outflow tract planes with color Doppler imaging. In 13, CHD was isolated while seven had extracardiac anomalies. Thirteen fetuses had aneuploidy and all 13 underwent first\u2010trimester termination of pregnancy. In the remaining seven, second\u2010trimester echocardiography and neonatal echo\/postmortem examination confirmed anomalies (two stillborn neonates, one neonatal death, four live births). Two cases of CHD missed by first\u2010trimester STIC\u2010TUI echo were diagnosed on second\u2010trimester echo. Accordingly, first\u2010trimester STIC\u2010TUI echo had 91% sensitivity and 100% specificity for the detection of CHD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>First\u2010trimester 4D echocardiography using a standardized application of STIC, TUI and color Doppler imaging is effective in displaying the imaging planes that are necessary for achieving the diagnosis of complex cardiac anomalies in high\u2010risk patients. Optimal imaging of the four\u2010chamber view with two\u2010dimensional ultrasound is the major determinant of successful volume acquisition. Copyright \u00a9 2014 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.13341","type":"journal-article","created":{"date-parts":[[2014,3,3]],"date-time":"2014-03-03T09:31:27Z","timestamp":1393839087000},"page":"562-567","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["First\u2010trimester fetal cardiac examination using spatiotemporal image correlation, tomographic ultrasound and color Doppler imaging for the diagnosis of complex congenital heart disease in high\u2010risk patients"],"prefix":"10.1002","volume":"44","author":[{"given":"S.","family":"Turan","sequence":"first","affiliation":[{"name":"Department of Obstetrics, Gynecology &amp; Reproductive Sciences University of Maryland School of Medicine  Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O. M.","family":"Turan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology &amp; Reproductive Sciences University of Maryland School of Medicine  Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Desai","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology &amp; Reproductive Sciences University of Maryland School of Medicine  Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. R.","family":"Harman","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology &amp; Reproductive Sciences University of Maryland School of Medicine  Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. A.","family":"Baschat","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology &amp; Reproductive Sciences University of Maryland School of Medicine  Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,10,15]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a113979"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.62.2.212"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.48.2.97"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.2677"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.6115"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5262"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.1922"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.6372"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.2803"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2006.25.2.187"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.2.550"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.9059"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1067\/S0002-9378(03)00645-8"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5350"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7570"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12548"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5273(88)90241-0"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(03)00913-X"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767050500127765"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12459"},{"key":"e_1_2_5_22_1","first-page":"496","article-title":"First\u2010trimester diagnosis of fetal congenital heart disease by transvaginal two\u2010dimensional and Doppler echocardiography","volume":"75","author":"Gembruch U","year":"1990","journal-title":"Obstet Gynecol"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.13341","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.13341","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T04:30:09Z","timestamp":1696480209000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.13341"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,15]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["10.1002\/uog.13341"],"URL":"https:\/\/doi.org\/10.1002\/uog.13341","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,15]]},"assertion":[{"value":"2013-10-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-02-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-10-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}