{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T12:08:37Z","timestamp":1785499717853,"version":"3.56.0"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,10,2]],"date-time":"2014-10-02T00:00:00Z","timestamp":1412208000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the prognostic value of the Children's Hospital Of Philadelphia (<jats:styled-content style=\"fixed-case\">CHOP<\/jats:styled-content>) cardiovascular score and the modified myocardial performance index (<jats:styled-content style=\"fixed-case\">MPI<\/jats:styled-content>), in determining the risk of recipient fetal loss in twin\u2010to\u2010twin transfusion syndrome (<jats:styled-content style=\"fixed-case\">TTTS<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cohort study was based on data collected prospectively from 105 pregnancies complicated by <jats:styled-content style=\"fixed-case\">TTTS<\/jats:styled-content> (Quintero stages I\u2013<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>) and treated with laser photocoagulation between May 2008 and February 2013. Fetuses underwent detailed anatomical and Doppler ultrasonography with cardiac assessment as part of routine care. <jats:styled-content style=\"fixed-case\">CHOP<\/jats:styled-content> score and right <jats:styled-content style=\"fixed-case\">MPI<\/jats:styled-content> were calculated and cut\u2010offs selected using receiver\u2013operating characteristics curve analysis. These were compared according to loss of recipient fetus, using univariate and multivariate logistic regression. The correlation between <jats:styled-content style=\"fixed-case\">CHOP<\/jats:styled-content> score, <jats:styled-content style=\"fixed-case\">MPI<\/jats:styled-content> and Quintero stage was determined and we investigated differences in <jats:styled-content style=\"fixed-case\">MPI<\/jats:styled-content> before and after laser coagulation in a cohort of 90 recipient fetuses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Rates of recipient fetal loss were significantly higher when the <jats:styled-content style=\"fixed-case\">CHOP<\/jats:styled-content> score was \u2265\u20093 (39.5% <jats:italic>vs<\/jats:italic> 12.9%, <jats:italic>P<\/jats:italic>\u2009=\u20090.002) and when <jats:styled-content style=\"fixed-case\">MPI<\/jats:styled-content> <jats:italic>z<\/jats:italic>\u2010score was &gt;\u20091.645 (34.5% <jats:italic>vs<\/jats:italic> 10.6%, <jats:italic>P<\/jats:italic>\u2009=\u20090.004). After adjustment for Quintero stage, the risk of recipient fetal loss remained significantly higher when the <jats:styled-content style=\"fixed-case\">CHOP<\/jats:styled-content> score was\u2009\u2265\u20093 (odds ratio, 3.09; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.035\u20139.21). There was a positive correlation between <jats:styled-content style=\"fixed-case\">CHOP<\/jats:styled-content> score, <jats:styled-content style=\"fixed-case\">MPI<\/jats:styled-content> and Quintero stage. <jats:styled-content style=\"fixed-case\">MPI<\/jats:styled-content> was significantly lower after compared with before laser coagulation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">CHOP<\/jats:styled-content> score and <jats:styled-content style=\"fixed-case\">MPI<\/jats:styled-content> are predictors of recipient fetal loss in <jats:styled-content style=\"fixed-case\">TTTS<\/jats:styled-content> and may be used to supplement Quintero's classification. Copyright \u00a9 2014 ISUOG. 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